| pubmed-article:18384744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18384744 | lifeskim:mentions | umls-concept:C1149367 | lld:lifeskim |
| pubmed-article:18384744 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18384744 | pubmed:dateCreated | 2008-6-2 | lld:pubmed |
| pubmed-article:18384744 | pubmed:abstractText | We have shown in two accompanying papers that TNF induces oscillations in (1) approximately 13% of the genome, and (2) the activation of MAP kinase and NF-kappaB signaling pathways. Here we aim to bridge oscillations in signal transduction activation to oscillations in genetic output. Specifically, we sought to study how these oscillations can combine in a ligand-specific manner at the level of the promoter to initiate gene transcription. We utilize the late onset gene CD38 as a model gene since it has previously been shown that TNF, but not the related cytokine RANK-L, induces its expression. We find that TNF-induced oscillations in p65 and p50 recruitment to the CD38 promoter correlated with recruitment of MAPK-induced AP-1 recruitment, as analyzed by quantitative ChIP analysis. Through re-ChIP analysis we show that a unique transcriptional complex is seen on the promoter at 3h post-TNF addition, corresponding to the onset of CD38 transcription, which is not seen in the basal state. Moreover, we show that RANK-L was unable to combinatorially recruit AP-1 and NF-kappaB transcription factors to the CD38 promoter, despite inducing the activation of both signaling pathways. These results, in sum with the two accompanying papers, constitute a new paradigm through which cells dynamically orchestrate signaling molecules to coordinate time-resolved gene transcription by the formation of novel time-specific transcriptional complexes. | lld:pubmed |
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| pubmed-article:18384744 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18384744 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18384744 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18384744 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18384744 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18384744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18384744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18384744 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18384744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18384744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18384744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18384744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18384744 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18384744 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18384744 | pubmed:author | pubmed-author:VioMM | lld:pubmed |
| pubmed-article:18384744 | pubmed:author | pubmed-author:IqbalJameelJ | lld:pubmed |
| pubmed-article:18384744 | pubmed:author | pubmed-author:ZaidiMoneM | lld:pubmed |
| pubmed-article:18384744 | pubmed:author | pubmed-author:YangGuozheG | lld:pubmed |
| pubmed-article:18384744 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18384744 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:18384744 | pubmed:volume | 371 | lld:pubmed |
| pubmed-article:18384744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18384744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18384744 | pubmed:pagination | 912-6 | lld:pubmed |
| pubmed-article:18384744 | pubmed:dateRevised | 2011-5-20 | lld:pubmed |
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| pubmed-article:18384744 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18384744 | pubmed:articleTitle | TNF-induced oscillations in combinatorial transcription factor binding. | lld:pubmed |
| pubmed-article:18384744 | pubmed:affiliation | Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, PO Box 1055, Endocrinology, New York, NY 10029, USA. | lld:pubmed |
| pubmed-article:18384744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18384744 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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