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pubmed-article:18381567pubmed:abstractTextCoronary artery bypass graft (CABG) surgery is frequently performed and effective; however, perioperative complications related to ischemia-reperfusion injury, including myocardial infarction (MI), remain common and result in significant morbidity and mortality. MC-1, a naturally occurring pyridoxine metabolite and purinergic receptor antagonist, prevents cellular calcium overload and may reduce ischemia-reperfusion injury. Phase 2 trial data suggest that MC-1 may reduce death or MI in high-risk patients undergoing CABG surgery.lld:pubmed
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pubmed-article:18381567pubmed:articleTitleEfficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.lld:pubmed
pubmed-article:18381567pubmed:affiliationDuke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715 , USA. john.h.alexander@duke.edulld:pubmed
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