| pubmed-article:18378296 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18378296 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:18378296 | lifeskim:mentions | umls-concept:C0032458 | lld:lifeskim |
| pubmed-article:18378296 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:18378296 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:18378296 | lifeskim:mentions | umls-concept:C0298987 | lld:lifeskim |
| pubmed-article:18378296 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:18378296 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18378296 | pubmed:dateCreated | 2008-6-16 | lld:pubmed |
| pubmed-article:18378296 | pubmed:abstractText | Polycyclic aromatic hydrocarbons (PAHs) are contaminants increasing in the environment largely due to burning of fossil fuels. Our previous work identified a synergistic toxicity interaction in zebrafish embryos occurring when PAHs that are agonists for the aryl hydrocarbon receptor (AHR) co-occur with PAHs that are CYP1A inhibitors. This toxicity is mediated by the AHR2, and morpholino knockdown of CYP1A exacerbated toxicity. This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a protective role similar to CYP1A. We used a morpholino approach to knockdown CYP1B1 alone and in co-knockdown with CYP1A to determine whether we could alter deformities caused by synergistic toxicity of PAHs. CYP1B1 knockdown was not different from non-injected controls; nor were CYP1B1+CYP1A co-knockdown deformities different from CYP1A knockdown alone. These data suggest that CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection. | lld:pubmed |
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| pubmed-article:18378296 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18378296 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18378296 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18378296 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18378296 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18378296 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18378296 | pubmed:issn | 0141-1136 | lld:pubmed |
| pubmed-article:18378296 | pubmed:author | pubmed-author:BuhlerDonald... | lld:pubmed |
| pubmed-article:18378296 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:18378296 | pubmed:author | pubmed-author:Timme-LaragyA... | lld:pubmed |
| pubmed-article:18378296 | pubmed:author | pubmed-author:NoyesPamela... | lld:pubmed |
| pubmed-article:18378296 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18378296 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:18378296 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18378296 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18378296 | pubmed:pagination | 85-7 | lld:pubmed |
| pubmed-article:18378296 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:meshHeading | pubmed-meshheading:18378296... | lld:pubmed |
| pubmed-article:18378296 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18378296 | pubmed:articleTitle | CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). | lld:pubmed |
| pubmed-article:18378296 | pubmed:affiliation | Nicholas School of the Environment and Earth Sciences and Integrated Toxicology and Environmental Health Program, Duke University, Durham, NC, USA. | lld:pubmed |
| pubmed-article:18378296 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18378296 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18378296 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:100150054 | entrezgene:pubmed | pubmed-article:18378296 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18378296 | lld:pubmed |
