pubmed-article:18375822 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0334634 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0174680 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C1420433 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C1424666 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C1415887 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C1419040 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0598086 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0598388 | lld:lifeskim |
pubmed-article:18375822 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
pubmed-article:18375822 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:18375822 | pubmed:dateCreated | 2008-4-16 | lld:pubmed |
pubmed-article:18375822 | pubmed:abstractText | Molecular mechanisms responsible for lymphoma resistance to apoptosis often involve the bcl-2 pathway. In this study, we investigated the cell signaling pathways activated in bcl-2-overexpressing human mantle cell lymphoma cell lines (JVM-2 and Z-138) that have been treated with oblimersen, a molecular gene silencing strategy that effectively suppresses bcl-2 in vitro and in vivo. Z-138 cells expressed higher levels of bcl-2 and were more sensitive to the effects of bcl-2 silencing, mediated by oblimersen or bcl-2 small interfering RNA, in vitro. Tumors derived following injection of Z-138 cells were sensitive to oblimersen as judged by decreases in tumor growth rate and decreases in cell proliferation (as measured by Ki-67). Immunohistochemistry and Western blot analysis of oblimersen-treated Z-138 tumors revealed a dose-dependent decrease in bcl-2 levels and an associated increase in the proapoptotic proteins caspase-3 and caspase-9. Silencing bcl-2 in Z-138 xenografts revealed an associated dose-dependent suppression of bax, a decrease in nuclear factor-kappaB and phospho-nuclear factor-kappaB, and transient loss of p53 levels. Coimmunoprecipitation studies suggest that the latter observation is mediated by an association between bcl-2 and phospho-mdm2. Bcl-2 silencing also led to p27 down-regulation and coimmunoprecipitation studies point to a role for bcl-2 in regulation of p27 localization/degradation. Bcl-2 silencing was also correlated with loss of cyclin D1a protein levels but not cyclin D1b levels. Coimmunoprecipitation studies indicate that bcl-2 may mediate its effects on cyclin D1a via interaction with p38 mitogen-activated protein kinase as well as a previously unreported interaction between bcl-2 and cyclin D1a. | lld:pubmed |
pubmed-article:18375822 | pubmed:language | eng | lld:pubmed |
pubmed-article:18375822 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18375822 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18375822 | pubmed:month | Apr | lld:pubmed |
pubmed-article:18375822 | pubmed:issn | 1535-7163 | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:GascoyneRandy... | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:KyleAlastair... | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:KlasaRichard... | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:ChikhGhaniaG | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:BallyMarcelM | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:MasinDanaD | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:KapanenAnita... | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:WilsonIan MIM | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:TuckerCatheri... | lld:pubmed |
pubmed-article:18375822 | pubmed:author | pubmed-author:HoffmanBrad... | lld:pubmed |
pubmed-article:18375822 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:18375822 | pubmed:volume | 7 | lld:pubmed |
pubmed-article:18375822 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18375822 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18375822 | pubmed:pagination | 749-58 | lld:pubmed |
pubmed-article:18375822 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:meshHeading | pubmed-meshheading:18375822... | lld:pubmed |
pubmed-article:18375822 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:18375822 | pubmed:articleTitle | Silencing Bcl-2 in models of mantle cell lymphoma is associated with decreases in cyclin D1, nuclear factor-kappaB, p53, bax, and p27 levels. | lld:pubmed |
pubmed-article:18375822 | pubmed:affiliation | Department of Advanced Therapeutics, BC Cancer Research Center, Vancouver, British Columbia, Canada V5Z 1L3. ctucker@bccrc.ca | lld:pubmed |
pubmed-article:18375822 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18375822 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:596 | entrezgene:pubmed | pubmed-article:18375822 | lld:entrezgene |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18375822 | lld:entrezgene |
lhgdn:association:21781 | lhgdn:found_in | pubmed-article:18375822 | lld:lhgdn |