| pubmed-article:18375719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0025465 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0035028 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18375719 | lifeskim:mentions | umls-concept:C0299477 | lld:lifeskim |
| pubmed-article:18375719 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18375719 | pubmed:dateCreated | 2008-5-7 | lld:pubmed |
| pubmed-article:18375719 | pubmed:abstractText | The perivascular sensory nerve (PvN) Ca(2+)-sensing receptor (CaR) is implicated in Ca(2+)-induced relaxation of isolated, phenylephrine (PE)-contracted mesenteric arteries, which involves the vascular endogenous cannabinoid system. We determined the effect of inhibition of diacylglycerol (DAG) lipase (DAGL), phospholipase A(2) (PLA(2)), and cytochrome P-450 (CYP) on Ca(2+)-induced relaxation of PE-contracted rat mesenteric arteries. Our findings indicate that Ca(2+)-induced vasorelaxation is not dependent on the endothelium. The DAGL inhibitor RHC 802675 (1 microM) and the CYP and PLA(2) inhibitors quinacrine (5 microM) (EC(50): RHC 802675 2.8 +/- 0.4 mM vs. control 1.4 +/- 0.3 mM; quinacrine 4.8 +/- 0.4 mM vs. control 2.0 +/- 0.3 mM; n = 5) and arachidonyltrifluoromethyl ketone (AACOCF(3), 1 microM) reduced Ca(2+)-induced relaxation of mesenteric arteries. Synthetic 2-arachidonoylglycerol (2-AG) and glycerated epoxyeicosatrienoic acids (GEETs) induced concentration-dependent relaxation of isolated arteries. 2-AG relaxations were blocked by iberiotoxin (IBTX) (EC(50): control 0.96 +/- 0.14 nM, IBTX 1.3 +/- 0.5 microM) and miconazole (48 +/- 3%), and 11,12-GEET responses were blocked by IBTX (EC(50): control 55 +/- 9 nM, IBTX 690 +/- 96 nM) and SR-141716A. The data suggest that activation of the CaR in the PvN network by Ca(2+) leads to synthesis and/or release of metabolites of the CYP epoxygenase pathway and metabolism of DAG to 2-AG and subsequently to GEETs. The findings indicate a role for 2-AG and its metabolites in Ca(2+)-induced relaxation of resistance arteries; therefore this receptor may be a potential target for the development of new vasodilator compounds for antihypertensive therapy. | lld:pubmed |
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| pubmed-article:18375719 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18375719 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18375719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18375719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18375719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18375719 | pubmed:month | May | lld:pubmed |
| pubmed-article:18375719 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:18375719 | pubmed:author | pubmed-author:BukoskiRichar... | lld:pubmed |
| pubmed-article:18375719 | pubmed:author | pubmed-author:DizDebra IDI | lld:pubmed |
| pubmed-article:18375719 | pubmed:author | pubmed-author:AwumeyEmmanue... | lld:pubmed |
| pubmed-article:18375719 | pubmed:author | pubmed-author:HillSylvie... | lld:pubmed |
| pubmed-article:18375719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18375719 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:18375719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18375719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18375719 | pubmed:pagination | H2363-70 | lld:pubmed |
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| pubmed-article:18375719 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18375719 | pubmed:articleTitle | Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. | lld:pubmed |
| pubmed-article:18375719 | pubmed:affiliation | Cardiovascular Disease Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA. eawumey@nccu.edu | lld:pubmed |
| pubmed-article:18375719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18375719 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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