| pubmed-article:18374904 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0002708 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0815105 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18374904 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18374904 | pubmed:dateCreated | 2008-4-18 | lld:pubmed |
| pubmed-article:18374904 | pubmed:abstractText | Conditioned taste aversion (CTA) learning occurs after the pairing of a novel taste with a toxin (e.g. sucrose with LiCl). The immediate early gene c-Fos is necessary for CTA learning, but c-Fos alone cannot be sufficient for consolidation. The expression of other AP-1 proteins from the Fos- and Jun-families may also be required shortly after conditioning for CTA consolidation. To screen for the expression of AP-1 transcription factors within small subregions, RT-PCR analysis was used after laser capture microdissection of the amygdala. Rats were infused intraorally with 5% sucrose (6 ml/6 min) or injected with LiCl (12 ml/kg, 0.15 M, i.p.) or given sucrose paired with LiCl (sucrose/LiCl), or not treated; 1 h later their brains were dissected. The lateral (LA), basolateral (BLA), and central (CeA) subnuclei of the amgydala of single 5 microm sections from individual rats were dissected using the Arcturus PixCell II system. Semi-quantitative RT-PCR showed the consistent presence of c-Fos, Fra-2, c-Jun, and JunD in the amygdala. In situ hybridization confirmed that c-Fos and Fra-2 mRNA expression was increased in the CeA after LiCl and sucrose/LiCl treatment. Immunohistochemistry for Fra-2 revealed high baseline levels of Fra-2 protein in the BLA and CeA, but also an increase in Fra-2 in the BLA and CeA after LiCl and sucrose/LiCl treatment. The similarity of response in LiCl and sucrose/LiCl treated groups might reflect activation by LiCl in both groups. To control for the effects of LiCl, rats were tested in a learned safety experiment. Fra-2 and c-Fos were examined in response to sucrose/LiCl in rats with prior familiarity with sucrose compared to rats without prior exposure to sucrose. The familiar (pre-exposure) group showed a significantly decreased number of Fra-2-positive cells compared with the novel group in the BLA, but not in the CeA. Because pre-exposure to sucrose attenuates CTA learning, a decreased cellular response in pre-exposed rats suggests a specific correlation with CTA learning. Changes in Fra-2 and c-Fos expression in the BLA and CeA at the time of conditioning, together with constitutive expression of c-Jun and JunD, may contribute to CTA learning. | lld:pubmed |
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| pubmed-article:18374904 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18374904 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18374904 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18374904 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18374904 | pubmed:month | May | lld:pubmed |
| pubmed-article:18374904 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:18374904 | pubmed:author | pubmed-author:HouptThomas... | lld:pubmed |
| pubmed-article:18374904 | pubmed:author | pubmed-author:KwonBumsupB | lld:pubmed |
| pubmed-article:18374904 | pubmed:author | pubmed-author:GoltzMarionM | lld:pubmed |
| pubmed-article:18374904 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18374904 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18374904 | pubmed:volume | 1207 | lld:pubmed |
| pubmed-article:18374904 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18374904 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18374904 | pubmed:pagination | 128-41 | lld:pubmed |
| pubmed-article:18374904 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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