| pubmed-article:18369468 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18369468 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:18369468 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:18369468 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18369468 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:18369468 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:18369468 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:18369468 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18369468 | pubmed:dateCreated | 2008-3-28 | lld:pubmed |
| pubmed-article:18369468 | pubmed:abstractText | Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. IFN-alpha/beta (type I IFN) and IFN-lambda (type III IFN) bind distinct receptors, but regulate similar sets of genes and exhibit strikingly similar biological activities. We analyzed to what extent the IFN-alpha/beta and IFN-lambda systems overlap in vivo in terms of expression and response. We observed a certain degree of tissue specificity in the production of IFN-lambda. In the brain, IFN-alpha/beta was readily produced after infection with various RNA viruses, whereas expression of IFN-lambda was low in this organ. In the liver, virus infection induced the expression of both IFN-alpha/beta and IFN-lambda genes. Plasmid electrotransfer-mediated in vivo expression of individual IFN genes allowed the tissue and cell specificities of the responses to systemic IFN-alpha/beta and IFN-lambda to be compared. The response to IFN-lambda correlated with expression of the alpha subunit of the IFN-lambda receptor (IL-28R alpha). The IFN-lambda response was prominent in the stomach, intestine and lungs, but very low in the central nervous system and spleen. At the cellular level, the response to IFN-lambda in kidney and brain was restricted to epithelial cells. In contrast, the response to IFN-alpha/beta was observed in various cell types in these organs, and was most prominent in endothelial cells. Thus, the IFN-lambda system probably evolved to specifically protect epithelia. IFN-lambda might contribute to the prevention of viral invasion through skin and mucosal surfaces. | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18369468 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18369468 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369468 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18369468 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18369468 | pubmed:issn | 1553-7374 | lld:pubmed |
| pubmed-article:18369468 | pubmed:author | pubmed-author:StaeheliPeter... | lld:pubmed |
| pubmed-article:18369468 | pubmed:author | pubmed-author:MichielsThoma... | lld:pubmed |
| pubmed-article:18369468 | pubmed:author | pubmed-author:SommereynsCar... | lld:pubmed |
| pubmed-article:18369468 | pubmed:author | pubmed-author:PaulSophieS | lld:pubmed |
| pubmed-article:18369468 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18369468 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:18369468 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18369468 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18369468 | pubmed:pagination | e1000017 | lld:pubmed |
| pubmed-article:18369468 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
| pubmed-article:18369468 | pubmed:meshHeading | pubmed-meshheading:18369468... | lld:pubmed |
