| pubmed-article:18360827 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C0205969 | lld:lifeskim |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C0237865 | lld:lifeskim |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:18360827 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:18360827 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18360827 | pubmed:dateCreated | 2008-4-16 | lld:pubmed |
| pubmed-article:18360827 | pubmed:abstractText | Thymomas and thymic carcinomas are peculiar epithelial tumors of the anterior mediastinum. They may show aggressive clinical behavior and are a paradigm for the interaction between the tumor and the immune system. So far, adequate functional studies enabling a better understanding of this malignancy have not been performed, since human thymoma/thymic carcinoma cell lines have not been available. Here, the authors describe the establishment, characterization and functional analyses of epithelial cell lines from a Type B1-thymoma and a poorly differentiated thymic carcinoma. By Fluorescence-activated cell sorting (FACS) analyses, both cell lines were aneuploid. The aneuploid cell fraction of the thymic carcinoma cell line was characterized by a high proliferation index of 55.9%, in contrast to a lower proliferation rate of the aneuploid cell fraction of the thymoma (19.7%). Array-based comparative genomic hybridization (aCGH) and conventional cytogenetic analysis of the thymoma revealed only minor imbalances whereas the thymic carcinoma was characterized by a complex karyotype in the hyperdiploid range that was readily defined with multicolor FISH (mFISH). Application of a selective COX-2 inhibitor reduced cell viability in both cell lines in a dose-dependent manner. In conclusion, these first cell lines of a thymoma and a CD5-positive thymic carcinoma are useful tools for further in vitro studies of cellular, molecular and genetic aspects of the disease and for functional tests to evaluate new therapeutic targets. | lld:pubmed |
| pubmed-article:18360827 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18360827 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18360827 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18360827 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18360827 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18360827 | pubmed:issn | 1097-0215 | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:LichterPeterP | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:GunawanBastia... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:RiekerRalf... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:SchirmacherPe... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:DienemannHend... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:EhemannVolker... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:KernMichael... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:SchnabelPhili... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:RadlwimmerBer... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:BreinigMarcoM | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:SchultenHans-... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:SchlaegerChri... | lld:pubmed |
| pubmed-article:18360827 | pubmed:author | pubmed-author:StegerChristi... | lld:pubmed |
| pubmed-article:18360827 | pubmed:copyrightInfo | (c) 2008 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:18360827 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18360827 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18360827 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:18360827 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18360827 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18360827 | pubmed:pagination | 2719-25 | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:meshHeading | pubmed-meshheading:18360827... | lld:pubmed |
| pubmed-article:18360827 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18360827 | pubmed:articleTitle | Establishment, characterization and drug sensitivity testing in primary cultures of human thymoma and thymic carcinoma. | lld:pubmed |
| pubmed-article:18360827 | pubmed:affiliation | Institute of Pathology, University Hospital, Heidelberg, Germany. | lld:pubmed |
| pubmed-article:18360827 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18360827 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
