| pubmed-article:18359628 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C0346647 | lld:lifeskim |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C0005682 | lld:lifeskim |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C1516170 | lld:lifeskim |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C0077938 | lld:lifeskim |
| pubmed-article:18359628 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:18359628 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18359628 | pubmed:dateCreated | 2008-4-15 | lld:pubmed |
| pubmed-article:18359628 | pubmed:abstractText | Derivatives of oleanolic acid, ursolic acid and glycyrrhetinic acid substituted with electron-withdrawing groups at the 2-position in the A-ring which also contains a 1-en-3-one structure are potent inhibitors of cancer cell growth. In this study, we have compared the effects of several 2-substituted analogs of triterpenoid acid methyl esters derived from ursolic and glycyrrhetinic acid on proliferation of KU7 and 253JB-V bladder and Panc-1 and Panc-28 pancreatic cancer cells. The results show that the 2-cyano and 2-trifluoromethyl derivatives were the most active compounds. The glycyrrhetinic acid derivatives with the rearranged C-ring containing the 9(11)-en-12-one structure were generally more active than the corresponding 12-en-11-one isomers. However, differences in growth inhibitory IC(50) values were highly variable and dependent on the 2-substituent (CN vs CF(3)) and cancer cell context. | lld:pubmed |
| pubmed-article:18359628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18359628 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18359628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18359628 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18359628 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18359628 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18359628 | pubmed:author | pubmed-author:SafeStephenS | lld:pubmed |
| pubmed-article:18359628 | pubmed:author | pubmed-author:McAleesAlanA | lld:pubmed |
| pubmed-article:18359628 | pubmed:author | pubmed-author:JutooruIndira... | lld:pubmed |
| pubmed-article:18359628 | pubmed:author | pubmed-author:ChadalapakaGa... | lld:pubmed |
| pubmed-article:18359628 | pubmed:author | pubmed-author:StefanacTomT | lld:pubmed |
| pubmed-article:18359628 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18359628 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18359628 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18359628 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18359628 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18359628 | pubmed:pagination | 2633-9 | lld:pubmed |
| pubmed-article:18359628 | pubmed:dateRevised | 2011-4-4 | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:meshHeading | pubmed-meshheading:18359628... | lld:pubmed |
| pubmed-article:18359628 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18359628 | pubmed:articleTitle | Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. | lld:pubmed |
| pubmed-article:18359628 | pubmed:affiliation | Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843-4466, USA. | lld:pubmed |
| pubmed-article:18359628 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18359628 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18359628 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18359628 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18359628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18359628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18359628 | lld:pubmed |
