| pubmed-article:18351459 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18351459 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:18351459 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18351459 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:18351459 | lifeskim:mentions | umls-concept:C0441843 | lld:lifeskim |
| pubmed-article:18351459 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18351459 | pubmed:dateCreated | 2008-9-15 | lld:pubmed |
| pubmed-article:18351459 | pubmed:abstractText | Group I mGluRs (mGluR1/5) are G-protein-coupled receptors and are abundantly expressed in most of medium spiny projection neurons in the striatum. Recent evidence demonstrates that group I mGluRs are among essential regulators for constitutive and inducible gene expression in host neurons. Upon activation, mGluR1/5 signals activate extracellular signal-regulated kinases (ERKs) which in turn phosphorylate transcription factors such as cAMP response element-binding protein (CREB) and Elk-1, and thereby facilitate immediate early gene and opioid peptide gene expression. The conventional mGluR1/5 signaling cascade (phosphoinositide hydrolysis and intracellular Ca(2+) release) participates in linking mGluR1/5 to ERK. Additionally, the prominent mGluR1/5 adaptor protein Homer contributes to assemble an efficient signaling apparatus connecting mGluR1/5 to gene expression. The mGluR1/5 linkage to transcription also functions in dopamine-stimulated gene expression. Together, the mGluR1/5-mediated gene expression constitutes a transcription-dependent mechanism underlying molecular adaptations and plasticity related to the pathogenesis of various mental illnesses. | lld:pubmed |
| pubmed-article:18351459 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18351459 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18351459 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18351459 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18351459 | pubmed:issn | 1573-6903 | lld:pubmed |
| pubmed-article:18351459 | pubmed:author | pubmed-author:WangJohn QJQ | lld:pubmed |
| pubmed-article:18351459 | pubmed:author | pubmed-author:LiuXian-YuXY | lld:pubmed |
| pubmed-article:18351459 | pubmed:author | pubmed-author:FibuchEugene... | lld:pubmed |
| pubmed-article:18351459 | pubmed:author | pubmed-author:MaoLi-MinLM | lld:pubmed |
| pubmed-article:18351459 | pubmed:author | pubmed-author:ZhangGuo-ChiG... | lld:pubmed |
| pubmed-article:18351459 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18351459 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:18351459 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18351459 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18351459 | pubmed:pagination | 1920-4 | lld:pubmed |
| pubmed-article:18351459 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18351459 | pubmed:meshHeading | pubmed-meshheading:18351459... | lld:pubmed |
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| pubmed-article:18351459 | pubmed:meshHeading | pubmed-meshheading:18351459... | lld:pubmed |
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| pubmed-article:18351459 | pubmed:meshHeading | pubmed-meshheading:18351459... | lld:pubmed |
| pubmed-article:18351459 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18351459 | pubmed:articleTitle | Group I metabotropic glutamate receptor-mediated gene expression in striatal neurons. | lld:pubmed |
| pubmed-article:18351459 | pubmed:affiliation | Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA. | lld:pubmed |
| pubmed-article:18351459 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18351459 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:18351459 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18351459 | lld:pubmed |
