| pubmed-article:18346716 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C0205095 | lld:lifeskim |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C0027028 | lld:lifeskim |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C0013470 | lld:lifeskim |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:18346716 | lifeskim:mentions | umls-concept:C1704419 | lld:lifeskim |
| pubmed-article:18346716 | pubmed:dateCreated | 2008-4-18 | lld:pubmed |
| pubmed-article:18346716 | pubmed:abstractText | We compared the abilities of cholecystokinin-33 (CCK-33) and CCK-8 to reduce food intake and to activate feeding-related areas of the nervous system. (1) Overnight food-deprived rats were presented with a 10% sucrose solution, and intake was measured at 5-min intervals throughout a 90-min test beginning immediately after intraperitoneal injections of 1, 3, or 5 nMol/kg of CCK-33, CCK-8, or the vehicle control. In the initial 20 min (first meal), both peptides were equally effective, producing large reductions of food intake. Thereafter, however, CCK-33 was more effective than CCK-8, producing much more sustained reductions. Overall, both peptides reduced total food intake, but CCK-33 was more effective than CCK-8. (2) Possible roles for the myenteric plexus of the duodenum and the dorsal vagal complex (DVC) of the brainstem in the differential satiety effects of CCK-33 and CCK-8 were examined by quantifying CCK-33- and CCK-8-stimulated Fos-like immunoreactivity (Fos-LI) in each site. Consistent with the greater ability of CCK-33 to produce sustained inhibitions of food intake, CCK-33 produced more Fos-LI than CCK-8 in nearly every section of the sampled sites. The results demonstrate: (1) Different forms of CCK have different efficacies in reducing food intake; (2) CCK-33 produces a much more prolonged satiety action than CCK-8; and (3) the myenteric plexus and DVC may play roles in these differential satiety actions. | lld:pubmed |
| pubmed-article:18346716 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18346716 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18346716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18346716 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18346716 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18346716 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:GreenGary MGM | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:ReeveJoseph... | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:MoyerLauraL | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:SayeghAyman... | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:RaboinShannon... | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:CooperMarvis... | lld:pubmed |
| pubmed-article:18346716 | pubmed:author | pubmed-author:AbdallaMohame... | lld:pubmed |
| pubmed-article:18346716 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18346716 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:18346716 | pubmed:volume | 1205 | lld:pubmed |
| pubmed-article:18346716 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18346716 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18346716 | pubmed:pagination | 27-35 | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
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| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:meshHeading | pubmed-meshheading:18346716... | lld:pubmed |
| pubmed-article:18346716 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18346716 | pubmed:articleTitle | Cholecystokinin-33 is more effective than cholecystokinin-8 in inhibiting food intake and in stimulating the myenteric plexus and dorsal vagal complex. | lld:pubmed |
| pubmed-article:18346716 | pubmed:affiliation | Gastroenterology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, USA. | lld:pubmed |
| pubmed-article:18346716 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18346716 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18346716 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
