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pubmed-article:18341346pubmed:abstractTextThe regio- and enantioselective cyclization of pyrroles onto N-acyliminium ions generated in situ from hydroxylactams is reported. Modest to excellent ee's and yields are obtained in these novel Pictet-Spengler-type reactions with a chiral thiourea-pyrrole catalyst. Useful synthetic transformations of the versatile pyrroloindolizidinone and pyrroloquinolizidinone products are presented.lld:pubmed
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pubmed-article:18341346pubmed:authorpubmed-author:JacobsenEric...lld:pubmed
pubmed-article:18341346pubmed:authorpubmed-author:RaheemIzzat...lld:pubmed
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pubmed-article:18341346pubmed:articleTitleRegio- and enantioselective catalytic cyclization of pyrroles onto N-acyliminium ions.lld:pubmed
pubmed-article:18341346pubmed:affiliationDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.lld:pubmed
pubmed-article:18341346pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18341346pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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