| pubmed-article:18339893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0597032 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0023690 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0026045 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C1366582 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0034634 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C1366622 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:18339893 | lifeskim:mentions | umls-concept:C0024779 | lld:lifeskim |
| pubmed-article:18339893 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18339893 | pubmed:dateCreated | 2008-6-2 | lld:pubmed |
| pubmed-article:18339893 | pubmed:abstractText | The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9, exerts apoptosis-inducing activity against various cells, especially tumor cells. Here, we present evidence that S100A8/A9 also has cell growth-promoting activity at low concentrations. Receptor of advanced glycation end product (RAGE) gene silencing and cotreatment with a RAGE-specific blocking antibody revealed that this activity was mediated via RAGE ligation. To investigate the signaling pathways, MAPK phosphorylation and NF-kappaB activation were characterized in S100A8/A9-treated cells. S100A8/A9 caused a significant increase in p38 MAPK and p44/42 kinase phosphorylation, and the status of stress-activated protein kinase/JNK phosphorylation remained unchanged. Treatment of cells with S100A8/A9 also enhanced NF-kappaB activation. RAGE small interfering RNA pretreatment abrogated the S100A8/A9-induced NF-kappaB activation. Our data indicate that S100A8/A9-promoted cell growth occurs through RAGE signaling and activation of NF-kappaB. | lld:pubmed |
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| pubmed-article:18339893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18339893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18339893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18339893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18339893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18339893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18339893 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18339893 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:ChazinWalter... | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:LosMarekM | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:WesselborgSeb... | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:KerkhoffClaus... | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:GhavamiSaeidS | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:HashemiMohamm... | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:EshraghiMehdi... | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:DattiloBrian... | lld:pubmed |
| pubmed-article:18339893 | pubmed:author | pubmed-author:RashediIranI | lld:pubmed |
| pubmed-article:18339893 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18339893 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:18339893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18339893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18339893 | pubmed:pagination | 1484-92 | lld:pubmed |
| pubmed-article:18339893 | pubmed:dateRevised | 2011-1-26 | lld:pubmed |
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