| pubmed-article:18337568 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C1334114 | lld:lifeskim |
| pubmed-article:18337568 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:18337568 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18337568 | pubmed:dateCreated | 2008-4-25 | lld:pubmed |
| pubmed-article:18337568 | pubmed:abstractText | CD4(+)CD25(+) regulatory T cells (CD25(+) Tregs) play a key role in immune regulation. Since hepatitis C virus (HCV) persists with increased circulating CD4(+)CD25(+) T cells and virus-specific effector T-cell dysfunction, we asked if CD4(+)CD25(+) T cells in HCV-infected individuals are similar to natural Tregs in uninfected individuals and if they include HCV-specific Tregs using the specific Treg marker FoxP3 at the single-cell level. We report that HCV-infected patients display increased circulating FoxP3(+) Tregs that are phenotypically and functionally indistinguishable from FoxP3(+) Tregs in uninfected subjects. Furthermore, HCV-specific FoxP3(+) Tregs were detected in HCV-seropositive persons with antigen-specific expansion, major histocompatibility complex class II/peptide tetramer binding affinity, and preferential suppression of HCV-specific CD8 T cells. Transforming growth factor beta contributed to antigen-specific Treg expansion in vitro, suggesting that it may contribute to antigen-specific Treg expansion in vivo. Interestingly, FoxP3 expression was also detected in influenza virus-specific CD4 T cells. In conclusion, functionally active and virus-specific FoxP3(+) Tregs are induced in HCV infection, thus providing targeted immune regulation in vivo. Detection of FoxP3 expression in non-HCV-specific CD4 T cells suggests that immune regulation through antigen-specific Treg induction extends beyond HCV. | lld:pubmed |
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| pubmed-article:18337568 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18337568 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
