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pubmed-article:18337095pubmed:abstractTextA family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 10nM to >20microM and were dependant upon both the nature of the aryl group and the tether joining the basic amine to the indolyl maleimide core of the inhibitors. Key interactions with the kinase ATP site and hinge region, predicted by homology modeling, were confirmed.lld:pubmed
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pubmed-article:18337095pubmed:articleTitleAryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation.lld:pubmed
pubmed-article:18337095pubmed:affiliationScios, Inc., 6500 Paseo Padre Parkway, Fremont, CA 94555, USA.lld:pubmed
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