| pubmed-article:18329887 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18329887 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:18329887 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:18329887 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18329887 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:18329887 | lifeskim:mentions | umls-concept:C1155873 | lld:lifeskim |
| pubmed-article:18329887 | lifeskim:mentions | umls-concept:C0031959 | lld:lifeskim |
| pubmed-article:18329887 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18329887 | pubmed:dateCreated | 2008-4-24 | lld:pubmed |
| pubmed-article:18329887 | pubmed:abstractText | We describe the synthesis of a series of DNA-threading bis(9-aminoacridine-4-carboxamides) comprising ethylpiperidino and N-methylpiperidin-4-yl sidechains, joined via neutral flexible alkyl chains, charged flexible polyamine chains and a semi-rigid charged piperazine linker. Their cytotoxicity towards human leukaemic cells gives IC(50) values ranging from 99 to 1100 nM, with the ethylpiperidino series generally being more cytotoxic than the N-methylpiperidin-4-yl series. Measurements with supercoiled DNA indicate that they bisintercalate. | lld:pubmed |
| pubmed-article:18329887 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18329887 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329887 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18329887 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329887 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329887 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329887 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329887 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18329887 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18329887 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18329887 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:WakelinLauren... | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:ZhangQingQ | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:StewartBernar... | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:HeZhicongZ | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:BuXianyongX | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:EleftheriouAl... | lld:pubmed |
| pubmed-article:18329887 | pubmed:author | pubmed-author:ZihlifMalikM | lld:pubmed |
| pubmed-article:18329887 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18329887 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18329887 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:18329887 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18329887 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18329887 | pubmed:pagination | 4390-400 | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:meshHeading | pubmed-meshheading:18329887... | lld:pubmed |
| pubmed-article:18329887 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18329887 | pubmed:articleTitle | DNA threading bis(9-aminoacridine-4-carboxamides): effects of piperidine sidechains on DNA binding, cytotoxicity and cell cycle arrest. | lld:pubmed |
| pubmed-article:18329887 | pubmed:affiliation | School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia. | lld:pubmed |
| pubmed-article:18329887 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18329887 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18329887 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18329887 | lld:pubmed |
