| pubmed-article:18322152 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18322152 | lifeskim:mentions | umls-concept:C0042449 | lld:lifeskim |
| pubmed-article:18322152 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:18322152 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:18322152 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18322152 | pubmed:dateCreated | 2008-5-16 | lld:pubmed |
| pubmed-article:18322152 | pubmed:abstractText | We hypothesized that the 5-hydroxytryptamine (5-HT; serotonin) system is present and functional in veins. In vena cava (VC), the presence of the 5-HT synthesis rate-limiting enzyme tryptophan hydroxylase-1 mRNA and accumulation of the 5-HT synthesis intermediate 5-hydroxytryptophan after incubation with tryptophan supported the ability of veins to synthesize 5-HT. The presence of 5-HT and its metabolite 5-hydroxyindole acetic acid was measured by high-performance liquid chromatography in VC and jugular vein (JV), and it was compared with similarly sized arteries aorta (RA) and carotid (CA), respectively. In rats treated with the monoamine oxidase-A (MAO-A) inhibitor pargyline to prevent 5-HT metabolism, basal 5-HT levels were higher in veins than in arteries. 5-HT uptake was observed after exposure to exogenous 5-HT in all vessels. The presence of MAO-A and the 5-HT transporter (SERT) in VC was observed by immunohistochemistry and Western analysis. However, 5-HT uptake was not inhibited by the SERT inhibitors fluoxetine and/or fluvoxamine in VC and JV, as opposed to the inhibition in RA and CA. Moreover, studies performed in VC from mutant rats lacking SERT showed no differences in 5-HT uptake compared with VC from wild type. These data suggest the SERT is not functional under physiological conditions in veins. The differences in 5-HT handling between veins and arteries may represent alternative avenues for targeting the 5-HT system in the peripheral circulation for controlling vascular tone. | lld:pubmed |
| pubmed-article:18322152 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18322152 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18322152 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18322152 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18322152 | pubmed:issn | 1521-0103 | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:YeeYY | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:KuhnDonald... | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:WattsStephani... | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:GeddesTimothy... | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:LinderA... | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:BurnettRobert... | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:SzaszTheodora... | lld:pubmed |
| pubmed-article:18322152 | pubmed:author | pubmed-author:DiazJessicaJ | lld:pubmed |
| pubmed-article:18322152 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18322152 | pubmed:volume | 325 | lld:pubmed |
| pubmed-article:18322152 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18322152 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18322152 | pubmed:pagination | 714-22 | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:meshHeading | pubmed-meshheading:18322152... | lld:pubmed |
| pubmed-article:18322152 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18322152 | pubmed:articleTitle | A serotonergic system in veins: serotonin transporter-independent uptake. | lld:pubmed |
| pubmed-article:18322152 | pubmed:affiliation | Department of Pharmacology and Toxicology, Michigan State University, B445 Life Sciences Bldg., East Lansing, MI 48824, USA. linderau@msu.edu | lld:pubmed |
| pubmed-article:18322152 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18322152 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18322152 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18322152 | lld:pubmed |
