Linked Life Data

18316365

Source:http://linkedlifedata.com/resource/pubmed/id/18316365

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SubjectPredicateObjectContext
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pubmed-article:18316365pubmed:dateCreated2008-7-31lld:pubmed
pubmed-article:18316365pubmed:abstractTextThe aim of this study is to investigate the correlation of high-sensitivity C-reactive protein and E-selectin with clinical manifestations and plaque characteristics in 88 patients (69 with and 19 without neurological symptoms) with high-grade stenosis of the carotid bifurcation who underwent endarterectomy. The grade of stenosis was quantified by duplex ultrasonography and digital subtraction angiography. Preoperatively, serum high-sensitivity C-reactive protein and E-selectin were measured. Postoperatively, carotid plaque morphology was established according to the American Heart Association classification. High-sensitivity C-reactive protein levels were significantly (P < .001) higher in symptomatic than in asymptomatic patients, as well as in patients with unstable compared with those with stable plaques (P < .001). Serum high-sensitivity C-reactive protein levels correlated significantly ( P < .05) with macrophage count on the plaque. In conclusion, serum high-sensitivity C-reactive protein levels are associated with presence of neurological symptoms and plaque instability in patients with high-grade stenosis of the carotid bifurcation.lld:pubmed
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pubmed-article:18316365pubmed:articleTitleHigh-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation.lld:pubmed
pubmed-article:18316365pubmed:affiliationDepartment of Vascular Surgery, General Hospital Georgios Gennimatas, Athens. pfanis@otenet.grlld:pubmed
pubmed-article:18316365pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18316365pubmed:publicationTypeComparative Studylld:pubmed
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