| pubmed-article:18314142 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C0026871 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C0034677 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18314142 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18314142 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18314142 | pubmed:dateCreated | 2008-4-3 | lld:pubmed |
| pubmed-article:18314142 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:abstractText | Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF. No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species. | lld:pubmed |
| pubmed-article:18314142 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18314142 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18314142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18314142 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18314142 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18314142 | pubmed:issn | 0025-326X | lld:pubmed |
| pubmed-article:18314142 | pubmed:author | pubmed-author:PeckM RMR | lld:pubmed |
| pubmed-article:18314142 | pubmed:author | pubmed-author:GuilherminoLL | lld:pubmed |
| pubmed-article:18314142 | pubmed:author | pubmed-author:LimbJJ | lld:pubmed |
| pubmed-article:18314142 | pubmed:author | pubmed-author:RotchellJ MJM | lld:pubmed |
| pubmed-article:18314142 | pubmed:author | pubmed-author:Rendón-Von... | lld:pubmed |
| pubmed-article:18314142 | pubmed:author | pubmed-author:SoaresA M V... | lld:pubmed |
| pubmed-article:18314142 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18314142 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:18314142 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18314142 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18314142 | pubmed:pagination | 633-40 | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:meshHeading | pubmed-meshheading:18314142... | lld:pubmed |
| pubmed-article:18314142 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18314142 | pubmed:articleTitle | Ras gene in marine mussels: a molecular level response to petrochemical exposure. | lld:pubmed |
| pubmed-article:18314142 | pubmed:affiliation | ICBAS - Instituto de Ciências Biomédicas de Abel Salazar, Departamento de Estudos de Populações, Laboratório de Ecotoxicologia, Universidade do Porto, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal. | lld:pubmed |
| pubmed-article:18314142 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18314142 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
