| pubmed-article:18313304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18313304 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:18313304 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18313304 | pubmed:dateCreated | 2008-4-24 | lld:pubmed |
| pubmed-article:18313304 | pubmed:abstractText | A novel series of 4-phenylisoquinolones were synthesized and evaluated as c-Jun N-terminal kinase (JNK) inhibitors. Initial modification at the 2- and 3-positions of the isoquinolone ring of hit compound 4, identified from high-throughput screening, led to the lead compound 6b. The optimization was carried out using a JNK1-binding model of 6b and several compounds exhibited potent JNK inhibition. Among them, 11g significantly inhibited cardiac hypertrophy in rat pressure-overload models without affecting blood pressure and the concept of JNK inhibitors as novel therapeutic agents for heart failure was confirmed. | lld:pubmed |
| pubmed-article:18313304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18313304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18313304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18313304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18313304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18313304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18313304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18313304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18313304 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18313304 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:JudsonII | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:YamaguchiMasa... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:ItohFumioF | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:KimuraHiroyuk... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:SogabeSatoshi... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:TamuraTomokoT | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:TanakaToshima... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:KawamotoTomoh... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:MatsumotoShin... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:AsanoYasutomi... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:KitamuraShuji... | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:OhraTaiichiT | lld:pubmed |
| pubmed-article:18313304 | pubmed:author | pubmed-author:AsoKazuyoshiK | lld:pubmed |
| pubmed-article:18313304 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18313304 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18313304 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:18313304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18313304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18313304 | pubmed:pagination | 4715-32 | lld:pubmed |
| pubmed-article:18313304 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:meshHeading | pubmed-meshheading:18313304... | lld:pubmed |
| pubmed-article:18313304 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18313304 | pubmed:articleTitle | Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1). | lld:pubmed |
| pubmed-article:18313304 | pubmed:affiliation | Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 17-85, Jusohonmachi 2-chome, Osaka 532-8686, Japan. Asano_Yasutomi@takeda.co.jp | lld:pubmed |
| pubmed-article:18313304 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18313304 | lld:chembl |
