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pubmed-article:18308653pubmed:abstractTextTamoxifen has antiestrogenic effects in the breast and estrogenlike activity in the skeletons of postmenopausal women. We hypothesized that postmenopausal women with breast cancer would experience a rapid decline in bone mineral density (BMD) after stopping tamoxifen, similar to that seen with estrogen withdrawal. The objective of this study was to assess, in a randomized, double-blind, placebo-controlled trial, whether administration of alendronate (70 mg weekly) would prevent bone loss associated with tamoxifen discontinuation.lld:pubmed
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pubmed-article:18308653pubmed:articleTitlePrevention of bone loss after withdrawal of tamoxifen.lld:pubmed
pubmed-article:18308653pubmed:affiliationDepartment of Medicine, Division of Endocrinology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.lld:pubmed
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