| pubmed-article:18296560 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C0009813 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C0149566 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C1760025 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C1261287 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C1412114 | lld:lifeskim |
| pubmed-article:18296560 | lifeskim:mentions | umls-concept:C2684089 | lld:lifeskim |
| pubmed-article:18296560 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18296560 | pubmed:dateCreated | 2008-4-2 | lld:pubmed |
| pubmed-article:18296560 | pubmed:abstractText | Recent studies from our laboratory demonstrated the importance of mechanosensitive epithelial Na(+) channel (ENaC) proteins in pressure-induced constriction in renal and cerebral arteries. ENaC proteins are closely related to acid-sensing ion channel 2 (ASIC2), a protein known to be required for normal mechanotransduction in certain sensory neurons. However, the role of the ASIC2 protein in pressure-induced constriction has never been addressed. The goal of the current study was to investigate the role of ASIC2 proteins in pressure-induced, or myogenic, constriction in the mouse middle cerebral arteries (MCAs) from ASIC2 wild-type (+/+), heterozygous (+/-), and null (-/-) mice. Constrictor responses to KCl (20-80 mM) and phenylephrine (10(-7)-10(-4) M) were not different among groups. However, vasoconstrictor responses to increases in intraluminal pressure (15-90 mmHg) were impaired in MCAs from ASIC2(-/-) and (+/-) mice. At 60 and 90 mmHg, MCAs from ASIC2(+/+) mice generated 13.7 +/- 2.1% and 15.8 +/- 2.0% tone and ASIC2(-/-) mice generated 7.4 +/- 2.8% and 12.5 +/- 2.4% tone, respectively. Surprisingly, MCAs from ASIC2(+/-) mice generated 1.2 +/- 2.2% and 3.9 +/- 1.8% tone at 60 and 90 mmHg. The reason underlying the total loss of myogenic tone in the ASIC2(+/-) is not clear, although the loss of mechanosensitive beta- and gamma-ENaC proteins may be a contributing factor. These results demonstrate that normal ASIC2 expression is required for normal pressure-induced constriction in the MCA. Furthermore, ASIC2 may be involved in establishing the basal level of myogenic tone. | lld:pubmed |
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| pubmed-article:18296560 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18296560 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18296560 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18296560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18296560 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18296560 | pubmed:issn | 0363-6135 | lld:pubmed |
| pubmed-article:18296560 | pubmed:author | pubmed-author:JerniganNikki... | lld:pubmed |
| pubmed-article:18296560 | pubmed:author | pubmed-author:HamiltonGinaG | lld:pubmed |
| pubmed-article:18296560 | pubmed:author | pubmed-author:DrummondHeath... | lld:pubmed |
| pubmed-article:18296560 | pubmed:author | pubmed-author:GrifoniSamira... | lld:pubmed |
| pubmed-article:18296560 | pubmed:author | pubmed-author:GannonKimberl... | lld:pubmed |
| pubmed-article:18296560 | pubmed:author | pubmed-author:Vanlandingham... | lld:pubmed |
| pubmed-article:18296560 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18296560 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:18296560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18296560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18296560 | pubmed:pagination | H1793-803 | lld:pubmed |
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| pubmed-article:18296560 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18296560 | pubmed:articleTitle | Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice. | lld:pubmed |
| pubmed-article:18296560 | pubmed:affiliation | Dept. of Physiology and Biophysics, Univesity of Mississippi Medical Center, Jackson, MS 39216-4505, USA. | lld:pubmed |
| pubmed-article:18296560 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18296560 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18296560 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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