| pubmed-article:18292809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C0018801 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C1151928 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C0010467 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:18292809 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:18292809 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18292809 | pubmed:dateCreated | 2008-3-4 | lld:pubmed |
| pubmed-article:18292809 | pubmed:abstractText | Hemodynamic overload in the heart can trigger maladaptive hypertrophy of cardiomyocytes. A key signaling event in this process is nuclear acetylation by histone deacetylases and p300, an intrinsic histone acetyltransferase (HAT). It has been previously shown that curcumin, a polyphenol responsible for the yellow color of the spice turmeric, possesses HAT inhibitory activity with specificity for the p300/CREB-binding protein. We found that curcumin inhibited the hypertrophy-induced acetylation and DNA-binding abilities of GATA4, a hypertrophy-responsive transcription factor, in rat cardiomyocytes. Curcumin also disrupted the p300/GATA4 complex and repressed agonist- and p300-induced hypertrophic responses in these cells. Both the acetylated form of GATA4 and the relative levels of the p300/GATA4 complex markedly increased in rat hypertensive hearts in vivo. The effects of curcumin were examined in vivo in 2 different heart failure models: hypertensive heart disease in salt-sensitive Dahl rats and surgically induced myocardial infarction in rats. In both models, curcumin prevented deterioration of systolic function and heart failure-induced increases in both myocardial wall thickness and diameter. From these results, we conclude that inhibition of p300 HAT activity by the nontoxic dietary compound curcumin may provide a novel therapeutic strategy for heart failure in humans. | lld:pubmed |
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| pubmed-article:18292809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18292809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292809 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:18292809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18292809 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18292809 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:HasegawaKojiK | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:WadaHiromichi... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:MorimotoTatsu... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:KawamuraTeruh... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:FujitaMasatos... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:KitaToruT | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:KomedaMasashi... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:ShimatsuAkira... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:NagasawaAtsus... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:TakayaTomohid... | lld:pubmed |
| pubmed-article:18292809 | pubmed:author | pubmed-author:SunagawaYoich... | lld:pubmed |
| pubmed-article:18292809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18292809 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:18292809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18292809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18292809 | pubmed:pagination | 868-78 | lld:pubmed |
| pubmed-article:18292809 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18292809 | pubmed:meshHeading | pubmed-meshheading:18292809... | lld:pubmed |
| pubmed-article:18292809 | pubmed:meshHeading | pubmed-meshheading:18292809... | lld:pubmed |
| pubmed-article:18292809 | pubmed:meshHeading | pubmed-meshheading:18292809... | lld:pubmed |
| pubmed-article:18292809 | pubmed:meshHeading | pubmed-meshheading:18292809... | lld:pubmed |
| pubmed-article:18292809 | pubmed:meshHeading | pubmed-meshheading:18292809... | lld:pubmed |
| pubmed-article:18292809 | pubmed:meshHeading | pubmed-meshheading:18292809... | lld:pubmed |
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| pubmed-article:18292809 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18292809 | pubmed:articleTitle | The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. | lld:pubmed |
| pubmed-article:18292809 | pubmed:affiliation | Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan. | lld:pubmed |
| pubmed-article:18292809 | pubmed:publicationType | Journal Article | lld:pubmed |
