| pubmed-article:18292536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18292536 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:18292536 | lifeskim:mentions | umls-concept:C2936626 | lld:lifeskim |
| pubmed-article:18292536 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:18292536 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18292536 | pubmed:dateCreated | 2008-2-22 | lld:pubmed |
| pubmed-article:18292536 | pubmed:abstractText | Alterations to the tumor microenvironment following localized irradiation may influence the effectiveness of subsequent immunotherapy. The objective of this study was to determine how IFN-gamma influences the inflammatory response within this dynamic environment following radiotherapy. B16/OVA melanoma cells were implanted into C57BL/6 (wild-type (WT)) and IFN-gamma-deficient (IFN-gamma-/-) mice. Seven days after implantation, mice received 15 Gy of localized tumor irradiation and were assessed 7 days later. Irradiation up-regulated the expression of VCAM-1 on the vasculature of tumors grown in WT but not in IFN-gamma-/- mice. Levels of the IFN-gamma-inducible chemokines MIG and IFN-gamma-inducible protein 10 were decreased in irradiated tumors from IFN-gamma-/- mice compared with WT. In addition to inducing molecular cues necessary for T cell infiltration, surface MHC class I expression is also up-regulated in response to IFN-gamma produced after irradiation. The role of IFN-gamma signaling in tumor cells on class I expression was tested using B16/OVA cells engineered to overexpress a dominant negative mutant IFN-gamma receptor (B16/OVA/DNM). Following implantation and treatment, expression of surface class I on tumor cells in vivo was increased in B16/OVA, but not in B16/OVA/DNM tumors, suggesting IFN-gamma acts directly on tumor cells to induce class I up-regulation. These increases in MHC class I expression correlated with greater levels of activated STAT1. Thus, IFN-gamma is instrumental in creating a tumor microenvironment conducive for T cell infiltration and tumor cell target recognition. | lld:pubmed |
| pubmed-article:18292536 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292536 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18292536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292536 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18292536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18292536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18292536 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18292536 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:18292536 | pubmed:author | pubmed-author:LordEdith MEM | lld:pubmed |
| pubmed-article:18292536 | pubmed:author | pubmed-author:FrelingerJohn... | lld:pubmed |
| pubmed-article:18292536 | pubmed:author | pubmed-author:GerberScott... | lld:pubmed |
| pubmed-article:18292536 | pubmed:author | pubmed-author:MoranJames... | lld:pubmed |
| pubmed-article:18292536 | pubmed:author | pubmed-author:LugadeAmit... | lld:pubmed |
| pubmed-article:18292536 | pubmed:author | pubmed-author:SorensenEliza... | lld:pubmed |
| pubmed-article:18292536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18292536 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18292536 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:18292536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18292536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18292536 | pubmed:pagination | 3132-9 | lld:pubmed |
| pubmed-article:18292536 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:meshHeading | pubmed-meshheading:18292536... | lld:pubmed |
| pubmed-article:18292536 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18292536 | pubmed:articleTitle | Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. | lld:pubmed |
| pubmed-article:18292536 | pubmed:affiliation | Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. | lld:pubmed |
| pubmed-article:18292536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18292536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18292536 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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