| pubmed-article:18289606 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18289606 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18289606 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:18289606 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18289606 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18289606 | pubmed:issue | 13-14 | lld:pubmed |
| pubmed-article:18289606 | pubmed:dateCreated | 2008-3-14 | lld:pubmed |
| pubmed-article:18289606 | pubmed:abstractText | Mast cells play a central role in allergic disease and host defense against several pathogens through the release of various bioactive compounds via degranulation. In this study, we found that a myristoylated pseudosubstrate of PKC-zeta (zeta-PS; myristoyl-SIYRRGARRWRKL, a PKC-zeta inhibitor) regulates mast cell degranulation. zeta-PS increased [Ca+2]i level at nanomolar concentrations in a PKC-zeta activity-independent manner in HMC-1 cells. Moreover, zeta-PS-induced [Ca+2]i generation was completely abrogated by phospholipase C (PLC), IP3 receptor or Galpha i/o inhibitor and zeta-PS potently induced degranulation in HMC-1 cells which was significantly inhibited by pretreating PLC inhibitors or a calcium chelator. Therefore, our results suggest that zeta-PS can induce degranulation in HMC-1 cells by triggering the calcium signal via a PKC-zeta-independent but Galpha i/o, PLC and IP3-dependent pathways. | lld:pubmed |
| pubmed-article:18289606 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18289606 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18289606 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18289606 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18289606 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:HWEIC CCC | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:RyuSung HoSH | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:SuhPann-Ghill... | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:KimJong... | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:KimJae IlJI | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:KimSun-HeeSH | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:KimYun-HeeYH | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:KimHyeon... | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:ChoiJung... | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:SongMinseokM | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:YeaKyungmooK | lld:pubmed |
| pubmed-article:18289606 | pubmed:author | pubmed-author:LimSeyoungS | lld:pubmed |
| pubmed-article:18289606 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18289606 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:18289606 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:18289606 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18289606 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18289606 | pubmed:pagination | 733-40 | lld:pubmed |
| pubmed-article:18289606 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
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| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:meshHeading | pubmed-meshheading:18289606... | lld:pubmed |
| pubmed-article:18289606 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18289606 | pubmed:articleTitle | A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity. | lld:pubmed |
| pubmed-article:18289606 | pubmed:affiliation | Department of Life Science, Division of Molecular and Life Science, Biotech Center, Pohang University of Science and Technology, San 31 Hyoja-Dong, Nam-Gu, Pohang, Kyungbuk 790-784, Republic of Korea. | lld:pubmed |
| pubmed-article:18289606 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18289606 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18289606 | lld:pubmed |
