| pubmed-article:18288867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18288867 | lifeskim:mentions | umls-concept:C1327133 | lld:lifeskim |
| pubmed-article:18288867 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:18288867 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:18288867 | lifeskim:mentions | umls-concept:C1518961 | lld:lifeskim |
| pubmed-article:18288867 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18288867 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18288867 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18288867 | pubmed:dateCreated | 2008-3-17 | lld:pubmed |
| pubmed-article:18288867 | pubmed:abstractText | beta-Hydroxy acids were reacted with hexafluoroacetone and carbodiimides to give carboxy-activated six-membered lactones in good yields. On reaction with amines, the corresponding amides were obtained. We demonstrate the following applications of this protecting/activating strategy: preparation of carboxamides in solution and on solid phase (both normal and reverse mode); recovery and reuse of the excess material in solid-phase synthesis; and convergent solid-phase peptide synthesis (CSPPS) with peptide segments bearing C-terminal Ser or Thr with very low levels of epimerization (<1%, HPLC). | lld:pubmed |
| pubmed-article:18288867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18288867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18288867 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18288867 | pubmed:issn | 0022-3263 | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:AlbericioFern... | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:RoyoMiriamM | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:BurgerKlausK | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:Ruíz-Rodrígue... | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:SpenglerJanJ | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:YraolaFrances... | lld:pubmed |
| pubmed-article:18288867 | pubmed:author | pubmed-author:WinterManfred... | lld:pubmed |
| pubmed-article:18288867 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18288867 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:18288867 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:18288867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18288867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18288867 | pubmed:pagination | 2311-4 | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:meshHeading | pubmed-meshheading:18288867... | lld:pubmed |
| pubmed-article:18288867 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18288867 | pubmed:articleTitle | A novel protecting/activating strategy for beta-hydroxy acids and its use in convergent peptide synthesis. | lld:pubmed |
| pubmed-article:18288867 | pubmed:affiliation | Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, E-08028 Barcelona, Spain. jan.spengler@irbbarcelona.com | lld:pubmed |
| pubmed-article:18288867 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18288867 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
