| pubmed-article:18288803 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18288803 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:18288803 | lifeskim:mentions | umls-concept:C1160466 | lld:lifeskim |
| pubmed-article:18288803 | lifeskim:mentions | umls-concept:C0037633 | lld:lifeskim |
| pubmed-article:18288803 | lifeskim:mentions | umls-concept:C1382100 | lld:lifeskim |
| pubmed-article:18288803 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:18288803 | lifeskim:mentions | umls-concept:C0596383 | lld:lifeskim |
| pubmed-article:18288803 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18288803 | pubmed:dateCreated | 2008-3-10 | lld:pubmed |
| pubmed-article:18288803 | pubmed:abstractText | A combination of controlled radical polymerization and azide-alkyne click chemistry was employed to prepare temperature-responsive block copolymer micelles conjugated with biological ligands with potential for active targeting of cancer tissues. Block copolymers of N-isopropylacrylamide (NIPAM) and N,N-dimethylacrylamide (DMA) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with an azido chain transfer agent (CTA). Pseudo-first-order kinetics and linear molecular weight dependence on conversion were observed for the RAFT polymerizations. CuI-catalyzed coupling with propargyl folate resulted in folic acid residues being efficiently conjugated to the alpha-azido chain ends of the homo and block copolymers. Temperature-induced self-assembly resulted in aggregates capable of controlled release of a model hydrophobic drug. CuI-catalyzed azide-alkyne cycloaddition has proven superior to conventional methods for conjugation of biological ligands to macromolecules, and the general strategy presented herein can potentially be extended to the preparation of folate-functionalized assemblies with other stimuli susceptibility (e.g., pH) for therapeutic and imaging applications. | lld:pubmed |
| pubmed-article:18288803 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18288803 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18288803 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18288803 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18288803 | pubmed:issn | 1526-4602 | lld:pubmed |
| pubmed-article:18288803 | pubmed:author | pubmed-author:SumerlinBrent... | lld:pubmed |
| pubmed-article:18288803 | pubmed:author | pubmed-author:DePriyadarsiP | lld:pubmed |
| pubmed-article:18288803 | pubmed:author | pubmed-author:GondiSudersha... | lld:pubmed |
| pubmed-article:18288803 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18288803 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:18288803 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18288803 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18288803 | pubmed:pagination | 1064-70 | lld:pubmed |
| pubmed-article:18288803 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:meshHeading | pubmed-meshheading:18288803... | lld:pubmed |
| pubmed-article:18288803 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18288803 | pubmed:articleTitle | Folate-conjugated thermoresponsive block copolymers: highly efficient conjugation and solution self-assembly. | lld:pubmed |
| pubmed-article:18288803 | pubmed:affiliation | Department of Chemistry, Southern Methodist University, 3215 Daniel Avenue, Dallas, Texas 75275-0314, USA. | lld:pubmed |
| pubmed-article:18288803 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18288803 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18288803 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18288803 | lld:pubmed |
