| pubmed-article:18287091 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C1415725 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C1235660 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18287091 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:18287091 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:18287091 | pubmed:dateCreated | 2008-4-14 | lld:pubmed |
| pubmed-article:18287091 | pubmed:abstractText | Ikaros and Notch1, two regulators of gene transcription, are critically important at many stages of T cell development. Deregulation of Ikaros and Notch activities cooperate to promote T cell leukemogenesis, providing evidence that they function in converging pathways in developing T cells. In this report, a mechanism for Ikaros:Notch cooperativity is described, revealing a non-redundant role for Ikaros in regulating expression of the Notch target gene Hes1 in a leukemia T cell line. We provide evidence that Ikaros directly represses Hes1 in concert with the transcriptional repressor, RBP-Jkappa, allowing for cross-talk between Notch and Ikaros that impacts regulation of CD4 expression. Taken together, these data describe a potential mechanism for Ikaros' function during T cell development and define Ikaros as an obligate repressor of Hes1. | lld:pubmed |
| pubmed-article:18287091 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18287091 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18287091 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18287091 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18287091 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18287091 | pubmed:author | pubmed-author:WinandySusanS | lld:pubmed |
| pubmed-article:18287091 | pubmed:author | pubmed-author:KathreinKatie... | lld:pubmed |
| pubmed-article:18287091 | pubmed:author | pubmed-author:ChariSheilaS | lld:pubmed |
| pubmed-article:18287091 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18287091 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:18287091 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18287091 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18287091 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18287091 | pubmed:pagination | 10476-84 | lld:pubmed |
| pubmed-article:18287091 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
| pubmed-article:18287091 | pubmed:meshHeading | pubmed-meshheading:18287091... | lld:pubmed |
