| pubmed-article:18276783 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0018837 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0282498 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0250400 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:18276783 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:18276783 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18276783 | pubmed:dateCreated | 2008-2-29 | lld:pubmed |
| pubmed-article:18276783 | pubmed:abstractText | The heat stress (HS)-induced increase in occludin protein expression has been postulated to be a protective response against HS-induced disruption of the intestinal epithelial tight junction barrier. The aim of this study was to elucidate the cellular and molecular processes that mediate the HS-induced up-regulation of occludin expression in Caco-2 cells. Exposure to HS (39 degrees C or 41 degrees C) resulted in increased expression of occludin protein; this was preceded by an increase in occludin mRNA transcription and promoter activity. HS-induced activation of heat shock factor-1 (HSF-1) resulted in cytoplasmic-to-nuclear translocation of HSF-1 and binding to its binding motif in the occludin promoter region. HSF-1 activation was associated with an increase in occludin promoter activity, mRNA transcription, and protein expression; which were abolished by the HSF-1 inhibitor quercetin. Targeted HSF-1 knock-down by siRNA transfection inhibited the HSF-1-induced increase in occulin expression and junctional localization of occulin protein. Site-directed mutagenesis of the HSF-1 binding motif in the occludin promoter region inhibited HS-induced binding of HSF-1 to the occludin promoter region and subsequent promoter activity. In conclusion, our data show for the first time that the HS-induced increase in occludin protein expression is mediated by HSF-1 activation and subsequent binding of HSF-1 to the occludin promoter, which initiates a series of molecular and cellular events culminating in increased junctional localization of occludin protein. | lld:pubmed |
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| pubmed-article:18276783 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18276783 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18276783 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18276783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18276783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18276783 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18276783 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:18276783 | pubmed:author | pubmed-author:YeDongmeiD | lld:pubmed |
| pubmed-article:18276783 | pubmed:author | pubmed-author:KennedyJohn... | lld:pubmed |
| pubmed-article:18276783 | pubmed:author | pubmed-author:MaThomas YTY | lld:pubmed |
| pubmed-article:18276783 | pubmed:author | pubmed-author:DokladnyKarol... | lld:pubmed |
| pubmed-article:18276783 | pubmed:author | pubmed-author:MoseleyPope... | lld:pubmed |
| pubmed-article:18276783 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18276783 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:18276783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18276783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18276783 | pubmed:pagination | 659-70 | lld:pubmed |
| pubmed-article:18276783 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18276783 | pubmed:meshHeading | pubmed-meshheading:18276783... | lld:pubmed |
