| pubmed-article:1826862 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0502330 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1826862 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:1826862 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1826862 | pubmed:dateCreated | 1991-5-30 | lld:pubmed |
| pubmed-article:1826862 | pubmed:abstractText | The influence of aging on T-cell activation and proliferation was examined in lymphocytes derived from peripheral blood, spleen, and lymph nodes of WBB6F1 C57B1/6J x WB/Re) mice. Following activation with anti-CD3 monoclonal antibodies, the greatest age-related changes were seen in CD4+ cells derived from spleens of 27- to 30-month-old mice. These CD4+ lymphocytes showed reduced [Ca2+]i signaling and decreased proliferation in the presence of exogenous interleukin 2. CD8+ cells from spleens of old animals showed reduced [Ca2+]i but not altered proliferation. Both CD4+ and CD8+ cells derived from peripheral blood of old mice showed decreased peak [Ca2+]i, but no defect in cell proliferation. In contrast, age-related deficits in either [Ca2+]i or proliferation were not observed in CD4+ and CD8+ cells from lymph nodes. Additionally, the percentage of CD4+ cells was decreased in all lymphoid organs from old mice, while the percentage of CD8+ cells was similar in lymphoid organs of old and young mice. Old mice had a significant increase in expression of Pgp-1 in CD4+ cells from spleen and peripheral blood and CD8+ cells derived from lymph node. Our studies indicate that there are differential effects of aging in T lymphocytes derived from different lymphoid organs in mice. Among the cell sources and subsets examined, the age-related changes noted in CD4+ cells from mouse peripheral blood were the most similar to those previously observed in the corresponding peripheral blood lymphocyte subset in humans. | lld:pubmed |
| pubmed-article:1826862 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1826862 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1826862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1826862 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1826862 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1826862 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:1826862 | pubmed:author | pubmed-author:RabinovitchP... | lld:pubmed |
| pubmed-article:1826862 | pubmed:author | pubmed-author:GrossmannAA | lld:pubmed |
| pubmed-article:1826862 | pubmed:author | pubmed-author:Maggio-PriceL... | lld:pubmed |
| pubmed-article:1826862 | pubmed:author | pubmed-author:JinnemanJ CJC | lld:pubmed |
| pubmed-article:1826862 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1826862 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:1826862 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1826862 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1826862 | pubmed:pagination | 118-31 | lld:pubmed |
| pubmed-article:1826862 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1826862 | pubmed:meshHeading | pubmed-meshheading:1826862-... | lld:pubmed |
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| pubmed-article:1826862 | pubmed:meshHeading | pubmed-meshheading:1826862-... | lld:pubmed |
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| pubmed-article:1826862 | pubmed:meshHeading | pubmed-meshheading:1826862-... | lld:pubmed |
| pubmed-article:1826862 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1826862 | pubmed:articleTitle | Influence of aging on intracellular free calcium and proliferation of mouse T-cell subsets from various lymphoid organs. | lld:pubmed |
| pubmed-article:1826862 | pubmed:affiliation | Department of Pathology, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:1826862 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1826862 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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