| pubmed-article:18267074 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18267074 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:18267074 | lifeskim:mentions | umls-concept:C0805701 | lld:lifeskim |
| pubmed-article:18267074 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18267074 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18267074 | pubmed:dateCreated | 2008-2-12 | lld:pubmed |
| pubmed-article:18267074 | pubmed:abstractText | Cytoplasmic polyadenylation plays a key role in the translational control of mRNAs driving biological processes such as gametogenesis, cell-cycle progression, and synaptic plasticity. What determines the distinct time of polyadenylation and extent of translational control of a given mRNA, however, is poorly understood. The polyadenylation-regulated translation is controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein, CPEB, which can assemble both translational repression or activation complexes. Using a combination of mutagenesis and experimental validation of genome-wide computational predictions, we show that the number and relative position of two elements, the CPE and the Pumilio-binding element, with respect to the polyadenylation signal define a combinatorial code that determines whether an mRNA will be translationally repressed by CPEB, as well as the extent and time of cytoplasmic polyadenylation-dependent translational activation. | lld:pubmed |
| pubmed-article:18267074 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18267074 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18267074 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18267074 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18267074 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18267074 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18267074 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:18267074 | pubmed:author | pubmed-author:LópezJosé... | lld:pubmed |
| pubmed-article:18267074 | pubmed:author | pubmed-author:GuigóRodericR | lld:pubmed |
| pubmed-article:18267074 | pubmed:author | pubmed-author:MéndezRaúlR | lld:pubmed |
| pubmed-article:18267074 | pubmed:author | pubmed-author:FoissacSylvai... | lld:pubmed |
| pubmed-article:18267074 | pubmed:author | pubmed-author:PiquéMariaM | lld:pubmed |
| pubmed-article:18267074 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18267074 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:18267074 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:18267074 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18267074 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18267074 | pubmed:pagination | 434-48 | lld:pubmed |
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| pubmed-article:18267074 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18267074 | pubmed:articleTitle | A combinatorial code for CPE-mediated translational control. | lld:pubmed |
| pubmed-article:18267074 | pubmed:affiliation | Centre for Genomic Regulation (CRG), UPF, C/Dr. Aiguader, 88, 08003 Barcelona, Spain. | lld:pubmed |
| pubmed-article:18267074 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18267074 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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