Linked Life Data

18262302

Source:http://linkedlifedata.com/resource/pubmed/id/18262302

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pubmed-article:18262302pubmed:abstractTextHepatitis B virus X protein (HBx) is involved in viral metabolism and progression of liver disease. Iron metabolism plays a significant role in liver disease. In this report, to elucidate the relationship between iron metabolism and HBx, we established the Huh7 cell lines in which HBx was stably expressed (Huh7-HBx). In Huh7-HBx, we observed that transferrin receptor 1 (TfR1) expression decreased and ferritin heavy chain (FtH) expression increased as well as reactive oxygen species (ROS) level increased. We also found that these modulations were caused by the downregulation of iron regulatory protein 1 (IRP1). Furthermore, the levels of total iron and labile iron pool (LIP) were altered in Huh7-HBx. In addition, antioxidant N-acetylcystein (NaC) increased IRP1 expression by depleting HBx-induced ROS. We also confirmed these alterations of TfR1 and FtH in the primary hepatocytes of HBx transgenic mice and in HepG2.2.15 cells that constitutively replicate the intact HBV genome. In conclusion, these results suggest that HBx modulates iron metabolism via ROS leading to pathological status in liver diseases.lld:pubmed
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pubmed-article:18262302pubmed:authorpubmed-author:SeongJe...lld:pubmed
pubmed-article:18262302pubmed:authorpubmed-author:LimSeung OeSOlld:pubmed
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pubmed-article:18262302pubmed:articleTitleHBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species.lld:pubmed
pubmed-article:18262302pubmed:affiliationDepartment of Biological Sciences, Seoul National University, 56-1 Shillim-dong, Kwanak-gu, Seoul 151-747, Republic of Korea.lld:pubmed
pubmed-article:18262302pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18262302pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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