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pubmed-article:1825687pubmed:abstractTextTo investigate the effect of pulmonary alveolar hypoxia on the synthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10% O2 or 5% O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.lld:pubmed
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pubmed-article:1825687pubmed:articleTitleAcute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats.lld:pubmed
pubmed-article:1825687pubmed:affiliationDepartment of Medicine, Kyoto University School of Medicine, Japan.lld:pubmed
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