| pubmed-article:18256459 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18256459 | lifeskim:mentions | umls-concept:C0080113 | lld:lifeskim |
| pubmed-article:18256459 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:18256459 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18256459 | pubmed:dateCreated | 2008-2-25 | lld:pubmed |
| pubmed-article:18256459 | pubmed:abstractText | Immortalized cell lines maintain telomeres by the expression of telomerase or by a mechanism designated alternative lengthening of telomeres (ALT). Although DNA polymerase alpha (pol-alpha) is reported to be required for telomere maintenance, the critical role of pol-alpha in telomere maintenance has not been firmly determined. We examined the role of retinoblastoma protein (pRb) and pol-alpha in the regulation of telomere length, using telomere-fiber FISH. Telomere length varied dependent on the intracellular abundance of pol-alpha or pRb in HeLa cells. A proportion of hyper-phosphorylated pRb (ppRb) molecules localized to sites of telomeric DNA replication in HeLa cells. Pol-alpha might thus contribute to telomere maintenance, and might be regulated by ppRb. | lld:pubmed |
| pubmed-article:18256459 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18256459 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18256459 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18256459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18256459 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18256459 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18256459 | pubmed:issn | 1347-6947 | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:TakemuraMasah... | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:YoshidaShonen... | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:SuzukiMotoshi... | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:YamadaYoshiji... | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:OkumuraKatsuz... | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:Limsirichaiku... | lld:pubmed |
| pubmed-article:18256459 | pubmed:author | pubmed-author:SugimuraKazut... | lld:pubmed |
| pubmed-article:18256459 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18256459 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:18256459 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18256459 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18256459 | pubmed:pagination | 630-5 | lld:pubmed |
| pubmed-article:18256459 | pubmed:meshHeading | pubmed-meshheading:18256459... | lld:pubmed |
| pubmed-article:18256459 | pubmed:meshHeading | pubmed-meshheading:18256459... | lld:pubmed |
| pubmed-article:18256459 | pubmed:meshHeading | pubmed-meshheading:18256459... | lld:pubmed |
| pubmed-article:18256459 | pubmed:meshHeading | pubmed-meshheading:18256459... | lld:pubmed |
| pubmed-article:18256459 | pubmed:meshHeading | pubmed-meshheading:18256459... | lld:pubmed |
| pubmed-article:18256459 | pubmed:meshHeading | pubmed-meshheading:18256459... | lld:pubmed |
| pubmed-article:18256459 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18256459 | pubmed:articleTitle | Hyper-phosphorylated retinoblastoma protein suppresses telomere elongation. | lld:pubmed |
| pubmed-article:18256459 | pubmed:affiliation | Department of Biology, Faculty of Science, Tokyo University of Science (RIKADAI), Japan. takemura@rs.kagu.tus.ac.jp | lld:pubmed |
| pubmed-article:18256459 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18256459 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
