| pubmed-article:1825481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1825481 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:1825481 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:1825481 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:1825481 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:1825481 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1825481 | pubmed:dateCreated | 1991-4-4 | lld:pubmed |
| pubmed-article:1825481 | pubmed:abstractText | Murine thymocytes are divided into four major populations on the basis of expression of CD4 and CD8 antigens. The bulk of evidence favours the view that CD4-CD8- cells can develop into CD4-CD8+ and CD4+CD8- cells via the CD4+CD8+ stage in the thymus. However, CD4-CD8+ and CD4+CD8- thymocyte subsets contain not only CD3+ mature cells but also CD3- immature cells, which seem to be intermediate cells between CD4-CD8- and CD4+CD8+ cells. Here we demonstrate mouse strain differences in the proportion of immature single-positive thymocyte subsets in thymus at the steady or developing state. In C3H mice, immature CD4+CD8- is dominant in proportion over CD4-CD8+ in foetal thymus and in donor-derived thymocytes at an early stage of bone marrow transplantation. On the other hand, immature CD4-CD8+ is dominant over CD4+CD8- during T-cell development in the case of B10.BR mice. An intermediate pattern was shown in the case of F1 mice. Both of these immature single-positive subsets gave rise to double-positive cells after 24 hr culture. These results suggest that there exist two distinct differential pathways; one is from CD4-CD8- cells to CD4+CD8+ cells via CD4-CD8+ cells, and another is via CD4+CD8- cells, and that an application of the 'CD8 pathway' or 'CD4 pathway' seems to be genetically destined by BM-derived cells but not by thymic stromal cells. | lld:pubmed |
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| pubmed-article:1825481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1825481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1825481 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1825481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1825481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1825481 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1825481 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1825481 | pubmed:author | pubmed-author:AsanoTT | lld:pubmed |
| pubmed-article:1825481 | pubmed:author | pubmed-author:MatsumotoKK | lld:pubmed |
| pubmed-article:1825481 | pubmed:author | pubmed-author:NomotoKK | lld:pubmed |
| pubmed-article:1825481 | pubmed:author | pubmed-author:AndoTT | lld:pubmed |
| pubmed-article:1825481 | pubmed:author | pubmed-author:MoroiYY | lld:pubmed |
| pubmed-article:1825481 | pubmed:author | pubmed-author:YoshikaiYY | lld:pubmed |
| pubmed-article:1825481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1825481 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:1825481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1825481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1825481 | pubmed:pagination | 20-6 | lld:pubmed |
| pubmed-article:1825481 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1825481 | pubmed:meshHeading | pubmed-meshheading:1825481-... | lld:pubmed |
| pubmed-article:1825481 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1825481 | pubmed:articleTitle | Two differential pathways from double-negative to double-positive thymocytes. | lld:pubmed |
| pubmed-article:1825481 | pubmed:affiliation | Department of Immunology, Kyushu University, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:1825481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1825481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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