| pubmed-article:1825347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C0142661 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C0162796 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C0023401 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C0872079 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C0031084 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:1825347 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:1825347 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1825347 | pubmed:dateCreated | 1991-3-27 | lld:pubmed |
| pubmed-article:1825347 | pubmed:abstractText | Recombinant A' protein could be reconstituted into U2 small nuclear ribonucleoprotein particles (snRNPs) upon addition to HeLa cell extracts as determined by coimmunoprecipitation and particle density; however, direct binding to U2 RNA could not be demonstrated except in the presence of the U2 snRNP B" protein. Mutational analysis indicated that a central core region of A' was required for particle reconstitution. This region consists of five tandem repeats of approximately 24 amino acids each that exhibit a periodicity of leucine and asparagine residues that is distinct from the leucine zipper. Similar leucine-rich (Leu-Leu motif) repeats are characteristic of a diverse array of soluble and membrane-associated proteins from yeasts to humans but have not been reported previously to reside in nuclear proteins. Several of these proteins, including Toll, chaoptin, RNase/angiogenin inhibitors, lutropin-choriogonadotropin receptor, carboxypeptidase N, adenylyl cyclase, CD14, and human immunodeficiency virus type 1 Rev, may be involved in protein-protein interactions. Our findings suggest that in cell extracts the Leu-Leu motif of A' is required for reconstitution with U2 snRNPs and perhaps with other components involved in splicing through protein-protein interactions. | lld:pubmed |
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| pubmed-article:1825347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1825347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1825347 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1825347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1825347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1825347 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1825347 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1825347 | pubmed:author | pubmed-author:KeeneJ DJD | lld:pubmed |
| pubmed-article:1825347 | pubmed:author | pubmed-author:FrescoL DLD | lld:pubmed |
| pubmed-article:1825347 | pubmed:author | pubmed-author:HarperD SDS | lld:pubmed |
| pubmed-article:1825347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1825347 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1825347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1825347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1825347 | pubmed:pagination | 1578-89 | lld:pubmed |
| pubmed-article:1825347 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
