| pubmed-article:18250416 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C1817959 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C1149210 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18250416 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18250416 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18250416 | pubmed:dateCreated | 2008-2-5 | lld:pubmed |
| pubmed-article:18250416 | pubmed:abstractText | The high-affinity chain of the IL-7 receptor, IL-7Ralpha (CD127), is expressed by effector CD8 T cells that have the capacity to become memory cells. IL-7Ralpha expression is uniformly high on naive CD8 T cells, and the majority of these cells down-regulate expression upon antigenic challenge. At the peak of expansion, the fraction of effectors expressing high IL-7Ralpha varies depending on the response examined. The signals that a CD8 T cell receives during a response to Ag that lead to altered expression of IL-7Ralpha have not been fully defined. In vitro experiments demonstrated that Ag alone is sufficient to down-regulate IL-7Ralpha on all cells and most of the cells rapidly re-express the receptor upon removal from Ag. Expression was not altered by the B7.1 costimulatory ligand or when IL-12 was present to provide the signal needed for development of effector functions, indicating that TCR engagement is sufficient to regulate IL-7Ralpha expression. Consistent with this, in vivo priming with peptide Ag resulted in IL-7Ralpha expression that inversely correlated with Ag levels, and expression levels were not changed when IL-12 or adjuvant were administered with Ag. A large fraction of the cells present at the peak of expansion had re-expressed IL-7Ralpha, but most of these cells failed to survive; those that did survive expressed high IL-7Ralpha levels. Thus, Ag-dependent signals regulate IL-7Ralpha levels on responding CD8 T cells, and this occurs whether the responding cells become fully activated or are rendered tolerant by administration of peptide Ag alone. | lld:pubmed |
| pubmed-article:18250416 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18250416 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18250416 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18250416 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18250416 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:18250416 | pubmed:author | pubmed-author:MescherMatthe... | lld:pubmed |
| pubmed-article:18250416 | pubmed:author | pubmed-author:HammerbeckChr... | lld:pubmed |
| pubmed-article:18250416 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18250416 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18250416 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:18250416 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18250416 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18250416 | pubmed:pagination | 2107-16 | lld:pubmed |
| pubmed-article:18250416 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:18250416 | pubmed:meshHeading | pubmed-meshheading:18250416... | lld:pubmed |
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| pubmed-article:18250416 | pubmed:meshHeading | pubmed-meshheading:18250416... | lld:pubmed |
| pubmed-article:18250416 | pubmed:meshHeading | pubmed-meshheading:18250416... | lld:pubmed |
| pubmed-article:18250416 | pubmed:meshHeading | pubmed-meshheading:18250416... | lld:pubmed |
| pubmed-article:18250416 | pubmed:meshHeading | pubmed-meshheading:18250416... | lld:pubmed |
| pubmed-article:18250416 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18250416 | pubmed:articleTitle | Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction. | lld:pubmed |
| pubmed-article:18250416 | pubmed:affiliation | Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA. | lld:pubmed |
| pubmed-article:18250416 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18250416 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16197 | entrezgene:pubmed | pubmed-article:18250416 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18250416 | lld:entrezgene |
