| pubmed-article:18245227 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C1522721 | lld:lifeskim |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C0038323 | lld:lifeskim |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C0034786 | lld:lifeskim |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:18245227 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:18245227 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18245227 | pubmed:dateCreated | 2008-3-3 | lld:pubmed |
| pubmed-article:18245227 | pubmed:abstractText | Sterol regulatory element-binding protein-1c (SREBP-1c) is a basic helix-loop-helix transcription factor that plays an important role in lipid homeostasis. Here, we show that SREBP-1c regulates androgen receptor (AR) transactivation through direct interaction with AR and represses androgen-dependent growth of prostatic cells. Transient transfection studies show that SREBP-1c specifically inhibits the transactivation of AR. Chromatin immunoprecipitation assays reveal that SREBP-1c is recruited with AR onto the endogenous AR target promoter. Moreover, adenovirus-mediated overexpression of SREBP-1c decreases the mRNA level of the prostate-specific antigen gene, an endogenous target gene of AR, supporting SREBP-1c modulation of AR transactivation. In vivo and in vitro protein interaction assays show that SREBP-1c directly interacts with AR through the activation function-1 domain of AR. In addition, transfection studies and glutathione S-transferase pull-down competition experiments reveal that the SREBP-1c-mediated repression of AR transactivation is accomplished through competition with certain AR coactivators for AR interaction. The SREBP-1c-mediated inhibition of AR transactivation also involves the recruitment of histone deacetylase 1. Finally, adenovirus-mediated overexpression of SREBP-1c inhibits androgen-induced proliferation of prostatic cells in vitro and in vivo, and small interfering RNA-mediated down-regulation of SREBP-1 enhances androgen-induced proliferation of prostatic cells as well as the transactivation of AR. Taken together, these results suggest that SREBP-1c acts as an AR corepressor and may play an important role in the regulation of AR-dependent prostatic cell growth. | lld:pubmed |
| pubmed-article:18245227 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18245227 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18245227 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18245227 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18245227 | pubmed:issn | 1541-7786 | lld:pubmed |
| pubmed-article:18245227 | pubmed:author | pubmed-author:ChoiHueng-Sik... | lld:pubmed |
| pubmed-article:18245227 | pubmed:author | pubmed-author:KimJae BumJB | lld:pubmed |
| pubmed-article:18245227 | pubmed:author | pubmed-author:LeeKeesookK | lld:pubmed |
| pubmed-article:18245227 | pubmed:author | pubmed-author:LeeIn-KyuIK | lld:pubmed |
| pubmed-article:18245227 | pubmed:author | pubmed-author:GongEun-Yeung... | lld:pubmed |
| pubmed-article:18245227 | pubmed:author | pubmed-author:SuhJi HoJH | lld:pubmed |
| pubmed-article:18245227 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18245227 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:18245227 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18245227 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18245227 | pubmed:pagination | 314-24 | lld:pubmed |
| pubmed-article:18245227 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:meshHeading | pubmed-meshheading:18245227... | lld:pubmed |
| pubmed-article:18245227 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18245227 | pubmed:articleTitle | Sterol regulatory element-binding protein-1c represses the transactivation of androgen receptor and androgen-dependent growth of prostatic cells. | lld:pubmed |
| pubmed-article:18245227 | pubmed:affiliation | Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea. | lld:pubmed |
| pubmed-article:18245227 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18245227 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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