| pubmed-article:18241232 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0021968 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0030054 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:18241232 | lifeskim:mentions | umls-concept:C0205332 | lld:lifeskim |
| pubmed-article:18241232 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18241232 | pubmed:dateCreated | 2008-3-6 | lld:pubmed |
| pubmed-article:18241232 | pubmed:abstractText | Intracellular adhesion molecule-1 (ICAM-1) expression on the thyroid follicular cells of non-obese diabetic (NOD).H2(h4) mice is enhanced by iodide treatment, which correlates with autoimmune thyroid disease in genetically susceptible NOD.H2(h4) mice. The current study examines the mechanism of iodine-enhanced up-regulation of ICAM-1 on the surface of thyroid cells. We hypothesized that the up-regulation of ICAM-1 is due to a transient increase in production of reactive oxygen species (ROS). ROS may initiate signalling of the ICAM-1 gene promoter, enhancing up-regulated ICAM-1 protein on the cell surface. Single-cell suspensions of thyroid follicular cells from thyroiditis-susceptible NOD.H2(h4) or non-susceptible BALB/c mice were treated in vitro with sodium iodide. Extracellular and intracellular ROS were assessed by luminol-derived chemiluminescence and flow cytometry assays respectively. Our results demonstrate that thyroid follicular cells of NOD.H2(h4) generate higher levels of ROS compared with cells from non-susceptible strains of mice. Expression of a subunit protein of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, p67(phox), was analysed by Western blot immunoassay. A constitutive expression of the p67(phox) subunit protein was observed in NOD.H2(h4) mice prior to iodine treatment. No such expression was found in BALB/c mice. Treatment of NOD.H2(h4) thyroid cells with diphenyleneiodium, an inhibitor of NADPH oxidase, reduced generation of ROS and of ICAM-1 protein expression. Thus, thyrocytes from NOD.H2(h4) mice produce enhanced levels of ROS that may be mediated by NADPH oxidase. Consequently, in NOD.H2(h4) mice the ROS-induced signal for ICAM-1 up-regulation may contribute to mononuclear cellular infiltration of the thyroid gland and the progression of autoimmune thyroid disease. | lld:pubmed |
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| pubmed-article:18241232 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18241232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18241232 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18241232 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18241232 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18241232 | pubmed:issn | 1365-2249 | lld:pubmed |
| pubmed-article:18241232 | pubmed:author | pubmed-author:SharmaRR | lld:pubmed |
| pubmed-article:18241232 | pubmed:author | pubmed-author:TrushM AMA | lld:pubmed |
| pubmed-article:18241232 | pubmed:author | pubmed-author:RoseN RNR | lld:pubmed |
| pubmed-article:18241232 | pubmed:author | pubmed-author:TraoreKK | lld:pubmed |
| pubmed-article:18241232 | pubmed:author | pubmed-author:BurekC... | lld:pubmed |
| pubmed-article:18241232 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18241232 | pubmed:volume | 152 | lld:pubmed |
| pubmed-article:18241232 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18241232 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18241232 | pubmed:pagination | 13-20 | lld:pubmed |
| pubmed-article:18241232 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18241232 | pubmed:meshHeading | pubmed-meshheading:18241232... | lld:pubmed |
| pubmed-article:18241232 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18241232 | pubmed:articleTitle | Intracellular adhesion molecule-1 up-regulation on thyrocytes by iodine of non-obese diabetic.H2(h4) mice is reactive oxygen species-dependent. | lld:pubmed |
| pubmed-article:18241232 | pubmed:affiliation | Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:18241232 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18241232 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:15894 | entrezgene:pubmed | pubmed-article:18241232 | lld:entrezgene |
| entrez-gene:111364 | entrezgene:pubmed | pubmed-article:18241232 | lld:entrezgene |
