| pubmed-article:18235083 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18235083 | lifeskim:mentions | umls-concept:C0035094 | lld:lifeskim |
| pubmed-article:18235083 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18235083 | lifeskim:mentions | umls-concept:C0019941 | lld:lifeskim |
| pubmed-article:18235083 | lifeskim:mentions | umls-concept:C0033382 | lld:lifeskim |
| pubmed-article:18235083 | lifeskim:mentions | umls-concept:C1425435 | lld:lifeskim |
| pubmed-article:18235083 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18235083 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18235083 | pubmed:dateCreated | 2008-3-28 | lld:pubmed |
| pubmed-article:18235083 | pubmed:abstractText | The prorenin/renin receptor is a recently discovered component of the renin-angiotensin system. The effects of aliskiren, a direct inhibitor of human renin, were compared with the handle region decoy peptide (HRP), which blocks the prorenin/renin receptor, in double-transgenic rats overexpressing the human renin and angiotensinogen genes. After 7 wk, all aliskiren-treated rats were alive, whereas mortality was 40% in vehicle-treated and 58% in HRP-treated rats. Aliskiren but not the HRP reduced BP and normalized albuminuria, cystatin C, and neutrophil gelatinase-associated lipocalin, a marker of renal tubular damage, to the levels of nontransgenic controls. In vitro, human renin and prorenin induced extracellular signal-regulated kinase 1/2 phosphorylation, independent of angiotensin II (AngII), in vascular smooth muscle cells. Preincubation with the HRP or aliskiren did not prevent renin- and prorenin-induced extracellular signal-regulated kinase 1/2 phosphorylation, whereas the MAP kinase kinase (MEK1/2) inhibitor PD98059 prevented both. In conclusion, renin inhibition but not treatment with the HRP protects against AngII-induced renal damage in double-transgenic rats. In addition, the in vitro data do not support the use of the HRP to block AngII-independent prorenin- or renin-mediated effects. | lld:pubmed |
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| pubmed-article:18235083 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18235083 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18235083 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18235083 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18235083 | pubmed:issn | 1533-3450 | lld:pubmed |
| pubmed-article:18235083 | pubmed:author | pubmed-author:LuftFriedrich... | lld:pubmed |
| pubmed-article:18235083 | pubmed:author | pubmed-author:DechendRalfR | lld:pubmed |
| pubmed-article:18235083 | pubmed:author | pubmed-author:MullerDominik... | lld:pubmed |
| pubmed-article:18235083 | pubmed:author | pubmed-author:FeldtSandraS | lld:pubmed |
| pubmed-article:18235083 | pubmed:author | pubmed-author:MaschkeUlrike... | lld:pubmed |
| pubmed-article:18235083 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18235083 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18235083 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18235083 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18235083 | pubmed:pagination | 743-8 | lld:pubmed |
| pubmed-article:18235083 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18235083 | pubmed:meshHeading | pubmed-meshheading:18235083... | lld:pubmed |
| pubmed-article:18235083 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18235083 | pubmed:articleTitle | The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. | lld:pubmed |
| pubmed-article:18235083 | pubmed:affiliation | Experimental and Clinical Research Center, Max-Delbruck-Center, Lindenberger Weg 80, 13125 Berlin, Germany. | lld:pubmed |
| pubmed-article:18235083 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18235083 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18235083 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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