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pubmed-article:1822788pubmed:abstractTextNatural abundance 13C NMR (nuclear magnetic resonance) spectroscopy was used to distinguish patients suffering from muscle glycogenosis type V (McArdle's disease) from normal subjects by measuring their muscle glycogen content at rest. Proton-decoupled 13C spectra were obtained in 10-15 min from calf muscles at rest. The ratio of the glycogen/creatine signal areas was 12.9 +/- 1.7 in four McArdle's disease patients and 2.0 +/- 0.7 in seven normal subjects. This technique thus allows the non-invasive diagnosis of muscle glycogenosis.lld:pubmed
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pubmed-article:1822788pubmed:articleTitleDiagnosis of muscular glycogenosis by in vivo natural abundance 13C NMR spectroscopy.lld:pubmed
pubmed-article:1822788pubmed:affiliationService Hospitalier Frederic Joliot, CEA, Orsay, France.lld:pubmed
pubmed-article:1822788pubmed:publicationTypeJournal Articlelld:pubmed
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