Combined inherited thrombophilia and adverse pregnancy outcome.

Source:http://linkedlifedata.com/resource/pubmed/id/18225686

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Authors

Kourounis G, Decavalas G, Sakellaropoulos G, Karakantza M, Mougiou A, Androutsopoulos G

Affiliation

Department of Obstetrics and Gynaecology, University of Patras, Medical School, Rion, Greece.

Abstract

Inherited thrombophilia has been suggested as a possible condition of increased susceptibility to adverse pregnancy outcomes. In our prospective study, we investigated the association between combined inherited thrombophilia and adverse pregnancy outcome in the South-Western Greek population. Three hundred and ninety-six healthy Greek women with spontaneous pregnancies were investigated for combinations of the three commonest thrombophilic mutations (Factor II G20210A, Factor V Leiden and MTHFR C677T) and followed for adverse pregnancy outcomes. Statistical analysis was performed by Pearson's chi-square test. Four women (1%) had the FV Leiden/MTHFR T677T double genotype and two women (0.5%) had the FII G20210A/MTHFR T677T double genotype. Although the small number of cases of combined inherited thrombophilia, it seems that the presence of FV Leiden/MTHFR T677T double genotype increases the risk for placental abruption.

PMID
18225686