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pubmed-article:18223278pubmed:abstractTextbackground: Mutations of the BCR-ABL tyrosine kinase domain constitute a major cause of resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia. We sought to improve the diagnostic armamentarium by screening and to analyze the dynamics of mutated clones in chronic myeloid leukemia patients who experienced hematologic or cytogenetic relapse.lld:pubmed
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pubmed-article:18223278pubmed:articleTitleDynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib.lld:pubmed
pubmed-article:18223278pubmed:affiliationIII. Medizinische Klinik, Medizinische, Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany.lld:pubmed
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