| pubmed-article:1821697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1821697 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1821697 | lifeskim:mentions | umls-concept:C0021013 | lld:lifeskim |
| pubmed-article:1821697 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:1821697 | lifeskim:mentions | umls-concept:C1621967 | lld:lifeskim |
| pubmed-article:1821697 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1821697 | pubmed:dateCreated | 1992-8-26 | lld:pubmed |
| pubmed-article:1821697 | pubmed:abstractText | Precursors of B cells capable of responding to a T-independent form of phosphorylcholine (PC) in splenic focus assays were detected in the spleens of neonatal mice as early as 4 days after birth. The earliest anti-PC B cells were T15-. T15+ foci-forming B cells were first detected 6 days after birth and expanded rapidly to constitute greater than 80% of the total PC-specific foci by day 10. Injection of heat-killed S. pneumoniae (R36A) into neonatal mice resulted in priming of the antibody response to PC, with an idiotype profile reflecting that of precursors of foci-forming B cells at the time of antigen administration. Priming of 2-day-old mice with 2 x 10(6) and 2 x 10(7) R36A induced a five- and ten-fold increase in the antibody response to phosphorylcholine 6 to 8 weeks later. However, only 10 to 15% of the serum antibodies expressed the normally dominant T15 idiotype. Doses below 2 x 10(5) R36A showed no detectable priming activity. PC-specific hybridomas derived from mice injected with 2 x 10(7) R36A 2 days after birth lacked the idiotypic and molecular characteristics typical of T15+ antibodies. Antibodies to phosphorylcholine, raised by immunization of 6-week-old mice are normally protective against pneumococcal infection. However, serum antibodies from mice treated with R36A 2 days after birth and responding to phosphorylcholine following challenge with R36A at 6 weeks of age failed to protect against deliberate infection with virulent S. pneumoniae. These observations imply that the antigen phosphorylcholine does not play a role in the selective expansion and dominant expression of the T15 idiotype. | lld:pubmed |
| pubmed-article:1821697 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1821697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1821697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1821697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1821697 | pubmed:issn | 1044-6672 | lld:pubmed |
| pubmed-article:1821697 | pubmed:author | pubmed-author:BrilesD EDE | lld:pubmed |
| pubmed-article:1821697 | pubmed:author | pubmed-author:KearneyJ FJF | lld:pubmed |
| pubmed-article:1821697 | pubmed:author | pubmed-author:VakilMM | lld:pubmed |
| pubmed-article:1821697 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1821697 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:1821697 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1821697 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1821697 | pubmed:pagination | 203-12 | lld:pubmed |
| pubmed-article:1821697 | pubmed:dateRevised | 2008-11-20 | lld:pubmed |
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| pubmed-article:1821697 | pubmed:meshHeading | pubmed-meshheading:1821697-... | lld:pubmed |
| pubmed-article:1821697 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1821697 | pubmed:articleTitle | Antigen-independent selection of T15 idiotype during B-cell ontogeny in mice. | lld:pubmed |
| pubmed-article:1821697 | pubmed:affiliation | Department of Microbiology, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:1821697 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1821697 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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