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pubmed-article:18213393pubmed:abstractTextHuman noroviruses are a highly diverse group of viruses classified into three of the five currently recognised Norovirus genogroups, and contain numerous genotypes or genetic clusters. Noroviruses are the major aetiological agent of endemic gastroenteritis in all age groups, as well as the cause of periodic epidemic gastroenteritis. The noroviruses most commonly associated with outbreaks of gastroenteritis are genogroup II genotype 4 (GII-4) strains. The relationship between genotypes of noroviruses with their phenotypes and antigenic profile remains poorly understood through an inability to culture these viruses and the lack of a suitable animal model.lld:pubmed
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pubmed-article:18213393pubmed:articleTitleAnalysis of amino acid variation in the P2 domain of the GII-4 norovirus VP1 protein reveals putative variant-specific epitopes.lld:pubmed
pubmed-article:18213393pubmed:affiliationEnteric Virus Unit, Virus Reference Department, Centre For Infections, Health Protection Agency, London, United Kingdom. david.james.allen@hpa.org.uklld:pubmed
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