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pubmed-article:1820924pubmed:abstractTextThe effect of the complexation with beta-cyclodextrin, hydroxypropyl beta-cyclodextrin and polyvinylpyrrolidone on the diffusion kinetics of hydrocortisone acetate through a non porous lipidic membrane was analyzed starting from different dermal bases: a Carbopol gel and lanovaseline. A constant diffusive gradient was achieved; this suggests that the complexation equilibrium controls the diffusable form, according to its stability constant. The following sequence was observed for the cumulative amount diffused: hydrocortisone acetate greater than hydrocortisone acetate/polyvinylpyrrolidone greater than hydrocortisone acetate/hydroxypropyl beta-cyclodextrin greater than hydrocortisone acetate/beta-cyclodextrin. Such behaviour was analyzed in terms of the main physical chemical parameters of the systems examined.lld:pubmed
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pubmed-article:1820924pubmed:pagination466-72lld:pubmed
pubmed-article:1820924pubmed:dateRevised2011-2-2lld:pubmed
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pubmed-article:1820924pubmed:articleTitleControlled release of hydrocortisone acetate from dermal bases.lld:pubmed
pubmed-article:1820924pubmed:affiliationDipartimento di Scienze Farmaceutiche, Bologna, Italy.lld:pubmed
pubmed-article:1820924pubmed:publicationTypeJournal Articlelld:pubmed
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