| pubmed-article:18200525 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18200525 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:18200525 | lifeskim:mentions | umls-concept:C0014806 | lld:lifeskim |
| pubmed-article:18200525 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:18200525 | lifeskim:mentions | umls-concept:C0011682 | lld:lifeskim |
| pubmed-article:18200525 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:18200525 | lifeskim:mentions | umls-concept:C0004916 | lld:lifeskim |
| pubmed-article:18200525 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18200525 | pubmed:dateCreated | 2008-8-5 | lld:pubmed |
| pubmed-article:18200525 | pubmed:abstractText | An in-line near infrared (NIR) spectrometer was employed to monitor phase transformations of erythromycin dihydrate during a miniaturized fluid bed drying process. The pellets, containing 50% (w/w) erythromycin dihydrate and 50% (w/w) microcrystalline cellulose, were dried at 30, 45, and 60 degrees C. Principal component analysis was used to determine solid-state changes. For this purpose the wavelength range of 1360-2000 nm was selected and preprocessed to remove multiplicative effects. Transformation to erythromycin dehydrate was observed for the pellets dried at 45 and 60 degrees C by NIR spectrometry and X-ray powder diffractometry (XRPD). The formation of erythromycin dehydrate was observed at a moisture content 1.4% (w/w) (mass of water per dry mass of sample) while at 1.8% (w/w) neither XRPD nor NIR were able to detect dehydration. Transformation to erythromycin dehydrate therefore depends strongly on the moisture content of the pellets. | lld:pubmed |
| pubmed-article:18200525 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18200525 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200525 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18200525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18200525 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18200525 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18200525 | pubmed:issn | 1520-6017 | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:HeinämäkiJyrk... | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:YliruusiJouko... | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:RantanenJukka... | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:MiroshnykInna... | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:SandlerNiklas... | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:RömerMeikeM | lld:pubmed |
| pubmed-article:18200525 | pubmed:author | pubmed-author:KivikeroNiina... | lld:pubmed |
| pubmed-article:18200525 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18200525 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:18200525 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18200525 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18200525 | pubmed:pagination | 4020-9 | lld:pubmed |
| pubmed-article:18200525 | pubmed:meshHeading | pubmed-meshheading:18200525... | lld:pubmed |
| pubmed-article:18200525 | pubmed:meshHeading | pubmed-meshheading:18200525... | lld:pubmed |
| pubmed-article:18200525 | pubmed:meshHeading | pubmed-meshheading:18200525... | lld:pubmed |
| pubmed-article:18200525 | pubmed:meshHeading | pubmed-meshheading:18200525... | lld:pubmed |
| pubmed-article:18200525 | pubmed:meshHeading | pubmed-meshheading:18200525... | lld:pubmed |
| pubmed-article:18200525 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18200525 | pubmed:articleTitle | Phase transformation of erythromycin A dihydrate during fluid bed drying. | lld:pubmed |
| pubmed-article:18200525 | pubmed:affiliation | Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, PO Box 56, 00014 Helsinki, Finland. meike.romer@helsinki.fi | lld:pubmed |
| pubmed-article:18200525 | pubmed:publicationType | Journal Article | lld:pubmed |
