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pubmed-article:18192899pubmed:abstractTextWe have found that in a laboratory strain of the nematode parasite of ruminants, Haemonchus contortus, repeated ivermectin treatment, in vivo in sheep, selected against TTC, coding for Phe, and for TAC, coding for Tyr, at codon 200 in beta-tubulin isotype 1. This 200Tyr single nucleotide polymorphism (SNP) has been associated with benzimidazole anthelmintic resistance. In this study, we investigated the alpha-tubulin and beta-tubulin sequences of 17 different field and laboratory strains/isolates of H. contortus with known treatment history and status for susceptibility or resistance to macrocyclic lactone (ML) or benzimidazole anthelmintics.lld:pubmed
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pubmed-article:18192899pubmed:authorpubmed-author:PrichardRoger...lld:pubmed
pubmed-article:18192899pubmed:authorpubmed-author:de Lourdes...lld:pubmed
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pubmed-article:18192899pubmed:year2008lld:pubmed
pubmed-article:18192899pubmed:articleTitleGenetic analysis of a relationship between macrocyclic lactone and benzimidazole anthelmintic selection on Haemonchus contortus.lld:pubmed
pubmed-article:18192899pubmed:affiliationInstitute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Quebec, Canada.lld:pubmed
pubmed-article:18192899pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18192899pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed