| pubmed-article:18192087 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18192087 | lifeskim:mentions | umls-concept:C0874159 | lld:lifeskim |
| pubmed-article:18192087 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:18192087 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:18192087 | lifeskim:mentions | umls-concept:C0280674 | lld:lifeskim |
| pubmed-article:18192087 | lifeskim:mentions | umls-concept:C0077938 | lld:lifeskim |
| pubmed-article:18192087 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:18192087 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18192087 | pubmed:dateCreated | 2008-9-12 | lld:pubmed |
| pubmed-article:18192087 | pubmed:abstractText | The inhibitory potency of ursolic acid extracted from Ilex paraguariensis, a plant used in South American population for a tea preparation known as maté, and its derivatives to inhibit aromatase activity was assessed and compared to a phytoestrogen apigenin and a steroidal aromatase inhibitor 4-hyroxyandrostenedione (4-OHA). Among all compounds tested only ursolic acid 1 showed an efficient and dose-dependent aromatase inhibition with IC50 value of 32 microM as did apigenin (IC50=10 microM), whereas IC50 value of 4-OHA was 0.8 microM. Our results show that the incorporation of a metallocene moiety into the ursolic acid derivatives decreases the aromatase inhibition. Moreover, comparison of the structure/inhibitory potency relationship of compounds indicates that the presence of cycle A and the configuration of C3-OH and C17-COOH seems to be more favourable to recognize the active site of aromatase and to block its activity. | lld:pubmed |
| pubmed-article:18192087 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18192087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18192087 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18192087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18192087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18192087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18192087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18192087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18192087 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18192087 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18192087 | pubmed:issn | 0223-5234 | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:MoslemiSafaS | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:GaléraPhilipp... | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:SonnetPascalP | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:Da... | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:GosmannGraceG | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:GnoattoSimone... | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:BoumedieneKar... | lld:pubmed |
| pubmed-article:18192087 | pubmed:author | pubmed-author:Dassonville-K... | lld:pubmed |
| pubmed-article:18192087 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18192087 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:18192087 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18192087 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18192087 | pubmed:pagination | 1865-77 | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:meshHeading | pubmed-meshheading:18192087... | lld:pubmed |
| pubmed-article:18192087 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18192087 | pubmed:articleTitle | Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. | lld:pubmed |
| pubmed-article:18192087 | pubmed:affiliation | Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil. | lld:pubmed |
| pubmed-article:18192087 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18192087 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18192087 | lld:chembl |
