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pubmed-article:18189348pubmed:abstractTextAccurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds in isocratic and gradient modes. Because UPLC columns are highly stable in basic pH conditions, this approach allows a direct lipophilicity estimation of basic compounds in their neutral forms.lld:pubmed
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pubmed-article:18189348pubmed:pagination396-9lld:pubmed
pubmed-article:18189348pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:18189348pubmed:year2008lld:pubmed
pubmed-article:18189348pubmed:articleTitleHigh-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists.lld:pubmed
pubmed-article:18189348pubmed:affiliationUnité de Pharmacochimie, School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Quai E-Ansermet 30, Geneva, Switzerland.lld:pubmed
pubmed-article:18189348pubmed:publicationTypeJournal Articlelld:pubmed
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